The effects of pre-enucleation irradiation on the development of metastases from intraocular Greene melanoma in hamsters.

Daniel Albert // Publications // Nov 15 1985

PubMed ID: 4061547

Author(s): Fournier GA, Saulenas AM, Seddon JM, Goitein M, Albert DM, Polivogianis L, Gragoudas E. The effects of pre-enucleation irradiation on the development of metastases from intraocular Greene melanoma in hamsters. Am J Ophthalmol. 1985 Nov 15;100(5):669-77. PMID 4061547

Journal: American Journal Of Ophthalmology, Volume 100, Issue 5, Nov 1985

Using intraocular Greene melanoma in a hamster model, we studied the effect of pre-enucleation irradiation on the development of melanoma metastases. One group (No. = 111) was treated with 1,210 to 1,600 rads of cobaltous chloride Co 60 gamma irradiation before enucleation and the second group (No. = 100) received no irradiation. The groups did not differ with respect to presence of metastases in the 106 days after tumor implantation (chi 2 = 3.05; P = .08). However, Kaplan-Meier survival curves gave a longer time to melanoma-related death in the irradiated animals compared with the controls (log rank test, P = .0008).