Ocular abnormalities associated with cutaneous melanoma and vitiligolike leukoderma.

Daniel Albert // Publications // Jan 01 1986

PubMed ID: 3792849

Author(s): Chang MA, Fournier G, Koh HK, Sober AJ, Nakagawa H, Fitzpatrick TB, Albert DM. Ocular abnormalities associated with cutaneous melanoma and vitiligolike leukoderma. Graefes Arch Clin Exp Ophthalmol. 1986;224(6):529-35. PMID 3792849

Journal: Graefe’s Archive For Clinical And Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, Volume 224, Issue 6, 1986

Several varieties of ocular pathology are associated with acquired cutaneous hypomelanosis (leukoderma; vitiligo). Our current study was undertaken to investigate the relationship between ophthalmologic disorders and a specific depigmentary phenomenon, the vitiligolike leukoderma of cutaneous melanoma. Over the past 14 years, eight patients with cutaneous melanoma and widespread areas of hypopigmentation were identified at the Pigmented Lesion Clinic of the Massachusetts General Hospital. The seven patients who underwent ophthalmologic examination had pigment-related ocular abnormalities. Among these were inflammations of the uveal tract in three patients, heterochromia in two, halo nevi of the choroid in one, and hypopigmentation and/or atrophy of the retinal pigment epithelium or choroid in four. Our findings demonstrate that ocular disease may be a component in a syndrome consisting also of cutaneous melanoma and vitiligolike leukoderma and suggest the need for complete ophthalmologic examinations in patients with melanoma and leukoderma.