Cystoid macular edema (CME) is commonly associated with many ocular conditions. The presence of CME on fluorescein angiographic examination need not, however, preclude good visual acuity. The hypothesis that the degree of macular thickening is associated with visual acuity was tested. Ten consecutive stereoscopic fluorescein angiograms were graded by 13 ophthalmologists using a set of four standards. Linear regression showed a significant relationship between mean macular thickening and the visual acuity recorded at the time of angiography. However, no significant relationship could be made between the estimation of visual acuity and the amount of fluorescein staining measured in the posterior pole. Although the observation of fluorescein leakage is indispensable for documenting a breakdown in the blood-retinal barrier, the observation of retinal thickening is important for identifying the sites of edema accumulation, and may be the useful parameter to follow when trying to assess improvement or worsening of retinal edema and in cases of uveitis when the cause of poor vision may be multifactorial.