Author(s): Fox LE, Grauer GF, Dubielzig RR, Bjorling DE. Reversal of ethylene glycol-induced nephrotoxicosis in a dog. J Am Vet Med Assoc. 1987 Dec 1;191(11):1433-5.
Journal: Journal Of The American Veterinary Medical Association, Volume 191, Issue 11, Dec 1987
Ethylene glycol-induced nephrotoxicosis was diagnosed in a dog with acute renal failure. Histologically, the dog had proximal tubular degeneration and necrosis, intraluminal calcium oxalate crystals, generally intact tubular basement membranes, and evidence of tubular regeneration. After 20 days of peritoneal dialysis and diuresis, renal function was adequate to maintain homeostasis without supportive care. Nine weeks after onset of the ethylene glycol-induced renal failure, the dog’s kidneys were histologically and functionally normal.