Author(s): Howard MA, Dryja TP, Walton DS, Albert DM. Identification and significance of multinucleate tumor cells in retinoblastoma. Arch Ophthalmol. 1989 Jul;107(7):1025-30. PMID 2751457
Journal: Archives Of Ophthalmology (Chicago, Ill. : 1960), Volume 107, Issue 7, Jul 1989
Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.