Harderian gland pathology in transgenic mice carrying the MMTV/v-Ha-ras gene.

Daniel Albert // Publications // Mar 01 1990

PubMed ID: 2156784

Author(s): White V, Sinn E, Albert DM. Harderian gland pathology in transgenic mice carrying the MMTV/v-Ha-ras gene. Invest Ophthalmol Vis Sci. 1990 Mar 1;31(3):577-81. PMID 2156784

Journal: Investigative Ophthalmology & Visual Science, Volume 31, Issue 3, Mar 1990

Twenty-four Harderian glands from 16 transgenic mice carrying a v-Ha-ras gene under the control of the mouse mammary tumor virus promoter were examined histologically upon death of the animals. Eight glands were histologically normal and eleven were hyperplastic. Four additional glands showed predominantly hyperplasia, but also contained foci of dysplasia and in situ carcinoma. One gland contained an adenocarcinoma. The range of pathology observed in the Harderian glands of these transgenic mice was similar to that which arises spontaneously, although hyperplasia, and not adenoma, occurred in these mice as the benign tumor.