Mitogenic effects of excitatory amino acids in the adult rat retina.

Daniel Albert // Publications // Nov 01 1991

PubMed ID: 1743264

Author(s): Sahel JA, Albert DM, Lessell S, Adler H, McGee TL, Konrad-Rastegar J. Mitogenic effects of excitatory amino acids in the adult rat retina. Exp Eye Res. 1991 Nov;53(5):657-64. PMID 1743264

Journal: Experimental Eye Research, Volume 53, Issue 5, Nov 1991

We studied the retinas of adult rats after the intravitreal injection of excitatory amino acids and ouabain. Kainic acid, domoic acid, N-methyl D-asparate and ouabain produced swelling and vacuolization of the outer plexiform, inner nuclear and inner plexiform layers and pyknosis. Mitoses were present in retinas treated with all agents other than N-methyl D-asparate. Rompun ketamine anesthesia blocked the mitogenic effects. Immunohistochemical labeling of both glial fibrillary acidic protein and S100 protein would indicate that the mitoses are occurring in glial cells. We suggest that the mitogenic effects are mediated through action on glial cationic channels, and might account for the reactive gliosis observed in some retinal lesions.