PubMed ID: 1730545
Author(s): Robinson JC, Kaufman PL. Superior cervical ganglionectomy in monkeys: surgical technique. Invest Ophthalmol Vis Sci. 1992 Jan;33(1):247-51. PMID 1730545
Journal: Investigative Ophthalmology & Visual Science, Volume 33, Issue 1, Jan 1992
Seven cynomolgus monkeys underwent a histologically confirmed left superior cervical ganglionectomy (SCGx). Unilateral ocular sympathetic denervation persisting for at least 2 yr was confirmed by ipsilateral ptosis, miosis, supersensitivity of pupillary dilation to topical phenylephrine, and profound pupillary hyporesponsiveness to topical hydroxyamphetamine. Intraocular pressure 8-9 and 23-27 months postoperatively were identical in the denervated and contralateral control eyes. This model should facilitate studies of aqueous humor physiology and pharmacology.