Author(s): Wallow IH, Sramek SJ, Bindley CD, Darjatmoko SR, Gange SJ. Ocular renin angiotensin: EM immunocytochemical localization of prorenin. Curr Eye Res. 1993 Oct;12(10):945-50. PMID 8293670
Journal: Current Eye Research, Volume 12, Issue 10, Oct 1993
Prorenin (PR) was localized by electron microscopic (EM) immunostaining of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunostaining. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, particularly in the vitreous cortex. This observation adds further evidence to a role of the ciliary epithelium in the transfer, storage or synthesis of components of a putative ocular renin angiotensin system.