Pattern of age-related maculopathy in the macular area. The Beaver Dam Eye Study.

Kleins Lab // Publications // Oct 01 1996

PubMed ID: 8843910

Author(s): Wang Q, Chappell RJ, Klein R, Eisner A, Klein BE, Jensen SC, Moss SE. Pattern of age-related maculopathy in the macular area. The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci. 1996 Oct;37(11):2234-42.

Journal: Investigative Ophthalmology & Visual Science, Volume 37, Issue 11, Oct 1996

PURPOSE To describe the distribution of lesions associated with age-related maculopathy by location in the macula in a population of adult Americans.

METHODS Four thousand nine hundred twenty-six persons ranging in age from 43 to 84 years and living in Beaver Dam, Wisconsin, at the time of a census (1987-1988) were examined from 1988 to 1990. Lesions typical of age-related maculopathy were determined by masked grading of stereoscopic color fundus photographs using the Wisconsin Age-Related Maculopathy Grading System. The extent and prevalence of different types of lesions were determined for each of nine macular subfield regions: central, inner superior, inner nasal, inner inferior, inner temporal, outer superior, outer nasal, outer inferior, and outer temporal.

RESULTS Lesions associated with early age-related maculopathy were distributed in specific patterns. Soft indistinct drusen were more prevalent in the temporal and superior quadrants than in the nasal and inferior quadrants, whereas pigmentary abnormalities associated with age-related maculopathy were more prevalent in the superior or nasal quadrants than in the inferior or temporal quadrants. After weighting for subfield area, all types of lesions were most prevalent in the central macular region.

CONCLUSION Various lesions associated with early age-related maculopathy were located in specific patterns in the macula. It is not known whether these patterns resulted from environmental, anatomic, or physiologic factors.