Choroidal innervation and optic neuropathy in macacque monkeys with laser- or anterior chamber perfusion-induced short-term elevation of intraocular pressure.

Kaufman Lab // Publications // Jun 01 2006

PubMed ID: 16466715

Author(s): Albrecht May C, Kaufman PL, L├╝tjen-Drecoll E, Scholz M. Choroidal innervation and optic neuropathy in macacque monkeys with laser- or anterior chamber perfusion-induced short-term elevation of intraocular pressure. Exp Eye Res. 2006 Jun;82(6):1060-7. Epub 2006 Feb 7. PMID 16466715

Journal: Experimental Eye Research, Volume 82, Issue 6, Jun 2006

Long-term intraocular pressure (IOP) elevation leads to a significant reduction of the intrinsic choroidal innervation and axon loss in the optic nerve. In this study we investigated early changes in these tissues in order to clarify the putative sequence of events between choroidal ganglion cell loss and optic nerve axon loss in 19 monkeys with experimentally induced glaucoma. After 1 month of increased IOP, severe optic neuropathy but no reduction of choroidal ganglion cells (CGC) was detectable. Beginning at 2 months after treatment signs of degeneration in CGC morphology were observed. Laser treatment of the trabecular meshwork without IOP elevation caused no changes in choroidal innervation. Our results show that there is no apparent association between reduction of CGC and optic neuropathy in the early stages of IOP elevation.