A statistical test of the hypothesis that polyclonal intestinal tumors arise by random collision of initiated clones.

Andrew Thliveris // Publications // Sep 01 2006

PubMed ID: 16984313

Author(s): Newton MA, Clipson L, Thliveris AT, Halberg RB. A statistical test of the hypothesis that polyclonal intestinal tumors arise by random collision of initiated clones. Biometrics. 2006 Sep;62(3):721-7. PMID 16984313

Journal: Biometrics, Volume 62, Issue 3, Sep 2006

The random collision hypothesis is a mathematical idealization of intestinal tumor formation that can account for the polyclonal origin of tumors without requiring a mechanistic description of clonal interaction. Using data from recent polyclonality studies in mice, we develop a statistical procedure to test the random collision hypothesis. Elements from stochastic geometry and approximations due to Armitage (1949, Biometrika 36, 257-266) support a statistical model of tumor count data. Bayesian analysis yields the posterior distribution of the number of heterotypic tumors, from which p-values are computed to test random collision.