Alcohol consumption and the 15-year cumulative incidence of age-related macular degeneration.

Kleins Lab // Publications // Jun 01 2007

PubMed ID: 17524768

Author(s): Knudtson MD, Klein R, Klein BE. Alcohol consumption and the 15-year cumulative incidence of age-related macular degeneration. Am J Ophthalmol. 2007 Jun;143(6):1026-9. PMID 17524768

Journal: American Journal Of Ophthalmology, Volume 143, Issue 6, Jun 2007

PURPOSE To investigate alcohol consumption as a risk factor for the 15-year cumulative incidence and progression of age-related macular degeneration (AMD).

DESIGN Prospective population-based study in Beaver Dam, WI with four examinations at five-year intervals initiated in 1988 (n = 3,509 contributed data for this analysis).

METHODS History of alcohol consumption was obtained via questionnaire. Cumulative incidence of early AMD, exudative AMD, pure geographic atrophy, and progression of AMD were assessed from fundus photographs taken at each examination.

RESULTS Heavy drinking (four or more drinks daily) at baseline was related to the 15-year cumulative incidence of pure geographic atrophy in men (odds ratio, 9.2; 95% confidence interval, 1.7 to 51.2). There were no consistent associations with the amount of beer, wine, or liquor consumption and the incidence or progression of AMD.

CONCLUSIONS Alcohol consumption is unlikely to strongly increase (or decrease) the risk of AMD.