Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA).

Kleins Lab // Publications // Jan 01 2009

PubMed ID: 19156628

Author(s): Kreis AJ, Wong TY, Islam FM, Klein R, Klein BE, Cotch MF, Jenkins AJ, Shea S, Wang JJ. Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The Multi-Ethnic Study of Atherosclerosis (MESA). Diab Vasc Dis Res. 2009 Jan;6(1):40-2. doi: 10.3132/dvdr.2009.008. PMID 19156628

Journal: Diabetes & Vascular Disease Research, Volume 6, Issue 1, Jan 2009

OBJECTIVE To examine the associations between nuclear magnetic resonance (NMR) defined lipoproteins and diabetic retinopathy (DR) in a population-based sample of adults with type 2 diabetes.

RESEARCH DESIGN AND METHODS In all, 921 persons with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) were included. DR was assessed from retinal photographs. Lipoproteins were measured by NMR spectroscopy.

RESULTS After controlling for age, race/ethnicity, study centre and diabetes and vascular risk factors, no consistent patterns of associations between NMR-defined lipoprotein particle concentrations and subclass with DR were evident.

CONCLUSION The lack of association between NMR-defined lipoproteins and DR does not support clinical use of NMR spectroscopy for management of patients with DR.