The role of the actomyosin system in regulating trabecular fluid outflow.

Kaufman Lab // Publications // Apr 01 2009

PubMed ID: 18793636

Author(s): Tian B, Gabelt BT, Geiger B, Kaufman PL. The role of the actomyosin system in regulating trabecular fluid outflow. Exp Eye Res. 2009 Apr;88(4):713-7. doi: 10.1016/j.exer.2008.08.008. Epub 2008 Aug 27. Review. PMID 18793636

Journal: Experimental Eye Research, Volume 88, Issue 4, Apr 2009

Abnormally high resistance to aqueous humor drainage via the trabecular meshwork and Schlemm’s canal is highly correlated with the development of primary open-angle glaucoma. Contractility of the actomyosin system in the trabecular cells or inner wall endothelium of Schlemm’s canal is an important factor in the regulation of outflow resistance. Cytoskeletal agents, affecting F-actin integrity or actomyosin contractility, or gene therapies, employing overexpression of caldesmon or Rho-A inhibition, can decrease outflow resistance in the drainage pathway. In this review, we discuss the mechanisms underlying these and similar effects on trabecular outflow resistance in living animals and/or in cultured ocular anterior segments from enucleated animal or human eyes.