Age-related macular degeneration and risk of coronary heart disease and stroke: the Cardiovascular Health Study.

Kleins Lab // Publications // Oct 01 2009

PubMed ID: 19592102

Author(s): Sun C, Klein R, Wong TY. age-related macular degeneration and risk of coronary heart disease and stroke: the Cardiovascular Health Study. Ophthalmology. 2009 Oct;116(10):1913-9. doi: 10.1016/j.ophtha.2009.03.046. Epub 2009 Jul 9. PMID 19592102

Journal: Ophthalmology, Volume 116, Issue 10, Oct 2009

PURPOSE To examine the associations of age-related macular degeneration (AMD) with incident coronary heart disease (CHD) and stroke in the Cardiovascular Health Study.

DESIGN Population-based prospective cohort study.

PARTICIPANTS A total of 1786 white and African-American participants free of CHD or 2228 participants free of stroke, aged 69 to 97 years.

METHODS AMD was evaluated from photographs taken in 1997 and 1998.

MAIN OUTCOME MEASURES Incident CHD and stroke ascertained using standardized methods.

RESULTS Of the 1786 persons free of CHD, 303 developed incident CHD over 7 years. Participants with early AMD (n = 277) had a higher cumulative incidence of CHD than participants without early AMD (25.8% vs. 18.9%, P = 0.001). By adjusting for age, gender, race, systolic and diastolic blood pressure, hypertension status, fasting glucose, triglyceride, low-density lipoprotein cholesterol, cigarette smoking, pack years of smoking, and C-reactive protein, the presence of early AMD was associated with an increased risk of incident CHD (hazard ratio 1.57; 95% confidence interval, 1.17-2.22). Late AMD (n = 25) was not associated with incident CHD (hazard ratio 0.78; 95% confidence interval, 0.25-2.48). Among 2228 persons at risk, 198 developed incident stroke; neither early nor late AMD was associated with incident stroke.

CONCLUSIONS This study suggests persons with early AMD have a higher risk of CHD but not stroke in a population aged 69 to 97 years. This provides further support that AMD is associated with underlying systemic vascular disease.