PubMed ID: 19841135
Author(s): Lakkaraju A, Carvajal-Gonzalez JM, Rodriguez-Boulan E. It takes two to tango to the melanosome. J Cell Biol. 2009 Oct 19;187(2):161-3. doi: 10.1083/jcb.200909100. PMID 19841135
Journal: The Journal Of Cell Biology, Volume 187, Issue 2, Oct 2009
The role of clathrin adaptor proteins in sorting cargo in the biosynthetic and recycling routes is an area of intense research. In this issue, Delevoye et al. (2009. J. Cell Biol. doi:10.1083/jcb.200907122) show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis.