Author(s): Hwang FS, Neekhra A, Lucarelli MJ, Warner TF, Snow SN, Albert DM. Sebaceous cell carcinoma of the eyelid: a rapidly enlarging lesion with massive xanthogranulomatous inflammation. Ophthalmic Plast Reconstr Surg. 2010 May-Jun;26(3):208-10. doi: 10.1097/IOP.0b013e3181c952b6. PMID 20489549
Journal: Ophthalmic Plastic And Reconstructive Surgery, Volume 26, Issue 3,
A 76-year-old man presented atypically with a 4-week history of a rapidly enlarging ulcerated nodular lesion of the left upper eyelid that was found to be sebaceous cell carcinoma. Further investigation showed no metastatic disease, and Mohs surgery was performed to resect the tumor. Histopathologic analysis showed features diagnostic of sebaceous cell carcinoma. However, most of the mass consisted of xanthomatous granulomatous inflammatory reaction vastly out of proportion with the tumor burden. The patient was spared from orbital exenteration, and no evidence of recurrence was present 6 months after resection.