Effects of low-level light therapy on streptozotocin-induced diabetic kidney.

PubMed ID: 20356759

Author(s): Lim J, Sanders RA, Snyder AC, Eells JT, Henshel DS, Watkins JB 3rd. Effects of low-level light therapy on streptozotocin-induced diabetic kidney. J Photochem Photobiol B. 2010 May 3;99(2):105-10. doi: 10.1016/j.jphotobiol.2010.03.002. Epub 2010 Mar 11. PMID 20356759

Journal: Journal Of Photochemistry And Photobiology. B, Biology, Volume 99, Issue 2, May 2010

Hyperglycemia causes oxidative damage in tissues prone to complications in diabetes. Low-level light therapy (LLLT) in the red to near infrared range (630-1000nm) has been shown to accelerate diabetic wound healing. To test the hypothesis that LLLT would attenuate oxidative renal damage in Type I diabetic rats, male Wistar rats were made diabetic with streptozotocin (50mg/kg, ip), and then exposed to 670nm light at a dose of 9J/cm(2) once per day for 14weeks. The activity and expression of catalase and the activity of Na K-ATPase increased in kidneys of light-treated diabetic rats, whereas the activity and expression of glutathione peroxidase and the expression of Na K-ATPase were unchanged. LLLT lowered the values of serum BUN, serum creatinine, and BUN/creatinine ratio. In addition, LLLT augmented the activity and expression of cytochrome c oxidase, a primary photoacceptor molecule in the mitochondrial respiratory chain, and reduced the formation of the DNA adduct 8-hydroxy-2′-deoxyguanosine in kidney. LLLT improved renal function and antioxidant defense capabilities in the kidney of Type I diabetic rats. Thus, 670nm LLLT may be broadly applicable to the amelioration of renal complications induced by diabetes that disrupt antioxidant defense mechanisms.