Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma.

Kaufman Lab // Publications // Jan 28 2011

PubMed ID: 20692280

Author(s): Ly T, Gupta N, Weinreb RN, Kaufman PL, Yücel YH. Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma. Vision Res. 2011 Jan 28;51(2):243-50. doi: 10.1016/j.visres.2010.08.003. Epub 2010 Aug 6. PMID 20692280

Journal: Vision Research, Volume 51, Issue 2, Jan 2011

Neural degeneration in glaucoma involves retinal ganglion cells and neurons of their major target, the lateral geniculate nucleus (LGN). Dendrites of relay LGN neurons projecting to the visual cortex were studied by immunocytochemical and quantitative Sholl analysis in combination with confocal microscopy and 3D-morphometry. In non-human adult primate glaucoma, relay LGN neurons showed reduced dendrite complexity and length, and these changes were modified by NMDA receptor blockade. Dendrite plasticity of LGN relay neurons in adult primate glaucoma has implications for potential disease modification by treatment interventions.

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