The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema.

PubMed ID: 21696702

Author(s): Hatef E, Colantuoni E, Wang J, Ibrahim M, Shulman M, Adhi F, Sepah YJ, Channa R, Khwaja A, Nguyen QD, Do DV. The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema. Am J Ophthalmol. 2011 Sep;152(3):400-405.e2. doi: 10.1016/j.ajo.2011.02.024. Epub 2011 Jun 21. PMID 21696702

Journal: American Journal Of Ophthalmology, Volume 152, Issue 3, Sep 2011

PURPOSE To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME).

DESIGN Prospective observational study.

METHODS settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness.

RESULTS Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (280 μm.

CONCLUSIONS In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.