Author(s): Sepah YJ, Hatef E, Colantuoni E, Wang J, Shulman M, Adhi FI, Akhtar A, Ibrahim M, Khwaja A, Channa R, Sophie R, Bittencourt M, Heo J, Do DV, Nguyen QD. Macular sensitivity and fixation patterns in normal eyes and eyes with uveitis with and without macular edema. J Ophthalmic Inflamm Infect. 2012 Jun;2(2):65-73. doi: 10.1007/s12348-011-0052-8. Epub 2011 Dec 14. PMID 22167465
Journal: Journal Of Ophthalmic Inflammation And Infection, Volume 2, Issue 2, Jun 2012
PURPOSE This study aims to investigate the relationship between macular sensitivity and thickness in eyes with uveitic macular edema (UME).
DESIGN This study is a prospective observational case series.
METHODS The setting for this study was clinical practice. The study included 59 (28 with UME, 31 without UME) eyes of 26 patients with uveitis and 19 eyes of 10 normal subjects. The procedure followed was fundus-related perimetry and retinal thickness map with an automated fundus perimetry/tomography system. Main outcome measures included quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and thickness.
RESULTS Fixation stability revealed that 56 eyes (93.44%) had stable fixation (>75% within the central 2° of point of fixation); three eyes (6.56%) were relatively unstable (75% located within 4°); and no eye had unstable fixation (50% of fixation point within 0.5 mm of foveal center); seven eyes (11.86%) had peri-central fixation location (25% << 50% within 0.5 mm); and seven eyes (11.86%) had eccentric (280 μm.
CONCLUSIONS Perimetry quantification of macular sensitivity and retinal thickness, in association with other factors, may offer novel information regarding the impact of UME on retinal function.