Noninvasive imaging of the thirteen-lined ground squirrel photoreceptor mosaic.

Alfredo Dubra // Publications // Jan 01 2016

PubMed ID: 26923645

Author(s): Sajdak B, Sulai YN, Langlo CS, Luna G, Fisher SK, Merriman DK, Dubra A. Noninvasive imaging of the thirteen-lined ground squirrel photoreceptor mosaic. Vis Neurosci. 2016;33:e003. doi: 10.1017/S0952523815000346. PMID 26923645

Journal: Visual Neuroscience, Volume 33, 2016

Ground squirrels are an increasingly important model for studying visual processing, retinal circuitry, and cone photoreceptor function. Here, we demonstrate that the photoreceptor mosaic can be longitudinally imaged noninvasively in the 13-lined ground squirrel (Ictidomys tridecemlineatus) using confocal and nonconfocal split-detection adaptive optics scanning ophthalmoscopy using 790 nm light. Photoreceptor density, spacing, and Voronoi analysis are consistent with that of the human cone mosaic. The high imaging success rate and consistent image quality in this study reinforce the ground squirrel as a practical model to aid drug discovery and testing through longitudinal imaging on the cellular scale.