A Novel Polyurethane Expandable Root Canal Sealer.

Publications // Sheibani Lab // Dec 23 2020

PubMed ID: 33359533

Author(s): Mohammad Ali SD, Karamifar K, Nath D, Gutmann JL, Sheibani N. A Novel Polyurethane Expandable Root Canal Sealer. J Endod. 2020 Dec 23. pii: S0099-2399(20)30962-6. doi: 10.1016/j.joen.2020.12.007. [Epub ahead of print] PMID 33359533

Journal: Journal Of Endodontics, Dec 2020

INTRODUCTION Endodontic sealers play a vital role in the obturation of root canal space. The aim of this study was to evaluate the utility of a recently developed Polyurethane Expandable Sealer (PES), along with its cytotoxicity and dimensional changes.

METHODS L929 fibroblasts and an MTS assay were used to determine the cytotoxicity of dental sealers (AH Plus, Sure-Seal Rootâ„¢, and the PES) at 24, 48, 72, and 96 hours. An advanced choroidal neovascularization (CNV) model was used to assess the effect of these sealers on angiogenesis. Thirty-six extracted single-rooted human teeth were prepared and randomly divided into three groups (n=12). Obturation was performed with gutta-percha and a sealer using lateral compaction: group 1 – AH Plus, group 2 – Sure-Seal, and group 3 – PES. The average depth of sealer penetration into dentinal tubules was measured with an SEM. Data were analyzed using one-way ANOVA and Post-hoc Tukey tests (level of significance, P <0.05).

RESULTS The values of MTS, CNV, and penetration depth of PES were significantly higher than in other experimental groups (P <0.05). The lowest values were seen in specimens of AH Plus, while the highest were detected in PES groups.

CONCLUSIONS PES showed promising results in terms of biocompatibility and dentinal tubules adaptation and penetration.

Published by Elsevier Inc.