Author(s): Saghiri MA, Karamifar K, Nath D, Gutmann JL, Sheibani N. A novel polyurethane expandable root canal sealer. J Endod. 2021 Apr;47(4):612-620. doi: 10.1016/j.joen.2020.12.007. Epub 2020 Dec 23. PMID 33359533
Journal: Journal Of Endodontics, Volume 47, Issue 4, Apr 2021
INTRODUCTION Endodontic sealers play a vital role in the obturation of root canal space. The aim of this study was to evaluate the utility of a recently developed polyurethane expandable sealer (PES), along with its cytotoxicity and dimensional changes.
METHODS L929 fibroblasts and an cell viability assay (MTS assay) were used to determine the cytotoxicity of dental sealers (AH Plus [Dentsply Maillefer, Ballaigues, Switzerland], Sure-Seal Root [Sure Dent Corporation, Gyeonggi-do, South Korea], and the PES) at 24, 48, 72, and 96 hours. An advanced choroidal neovascularization model was used to assess the effect of these sealers on angiogenesis. Thirty-six extracted single-rooted human teeth were prepared and randomly divided into 3 groups (n = 12). Obturation was performed with gutta-percha and a sealer using lateral compaction as follows: group 1, AH Plus; group 2, Sure-Seal; and group 3, PES. The average depth of sealer penetration into dentinal tubules was measured with a scanning electron microscope. Data were analyzed using 1-way analysis of variance and post hoc Tukey tests (level of significance, P < .05).
RESULTS The values of MTS, choroidal neovascularization, and the penetration depth of PES were significantly higher than in other experimental groups (P < .05). The lowest values were noted in specimens of AH Plus, whereas the highest were detected in the PES group.
CONCLUSIONS PES showed promising results in terms of biocompatibility and dentinal tubule adaptation and penetration.