PubMed ID: 35912101
Author(s): Mzyk P, Hernandez H, Le T, Ramirez JR, McDowell CM. Toll-Like Receptor 4 Signaling in the Trabecular Meshwork. Front Cell Dev Biol. 2022 Jul 15;10:936115. doi: 10.3389/fcell.2022.936115. eCollection 2022. Review. PMID 35912101
Journal: Frontiers In Cell And Developmental Biology, Volume 10, 2022
Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets. Recent evidence has implicated Toll-like receptor 4 (TLR4) and it is signaling pathway in augmenting the effects of transforming growth factor beta-2 (TGFβ2) and downstream extracellular matrix production. In this review, we examine the role of TLR4 signaling in the trabecular meshwork and the interplay between endogenous activators of TLR4 (damage-associated molecular patterns (DAMPs)), extracellular matrix (ECM), and the effect on intraocular pressure.
Copyright © 2022 Mzyk, Hernandez, Le, Ramirez and McDowell.