Host factors associated with either VP16 or VP16-induced complex differentially affect HSV-1 lytic infection.

PubMed ID: 36069169

Author(s): Ding X, Neumann DM, Zhu L. Host factors associated with either VP16 or VP16-induced complex differentially affect HSV-1 lytic infection. Rev Med Virol. 2022 Nov;32(6):e2394. doi: 10.1002/rmv.2394. Epub 2022 Sep 7. PMID 36069169

Journal: Reviews In Medical Virology, Volume 32, Issue 6, Nov 2022

Herpes simplex virus type 1 (HSV-1) is an important human pathogen with neurotropism. Following lytic infection in mucosal or skin epithelium, life-long latency is established mainly in sensory neurons, which can periodically reactivate by stress, leading to recurrent disease and virus transmission. During the virus’s productive infection, the tegument protein VP16, a component of HSV-1 virion, is physically associated with two cellular factors, host cell factor-1 (HCF-1), and POU domain protein Oct-1, to construct the VP16-induced complex, which is essential to stimulate immediate early (IE)-gene transcription as well as initiate the lytic programme. Apart from HCF-1 and Oct-1, VP16 also associates with a series of other host factors, making a VP16-induced regulatory switch to either activate or inactivate virus gene transcription. In addition, VP16 has effects on distinct signalling pathways via binding to various host molecules that are essentially related to innate immune responses, RNA polymerases, molecular chaperones, and virus infection-induced host shutoff. VP16 also functionally compensates for given host factors, such as PPAR-γ and ß-catenin. In this review, we provide an overview of the updated insights on the interplay between VP16 and the host factors that coordinate virus infection.