PubMed ID: 37339127
Author(s): Kiland JA, Terhaar HM, Walleck HE, Chen N, McDaniel K, McLellan GJ. Comparison of the TONOVET Plus(R), TonoVet(R), and Tono-Pen Vet tonometers in normal cats and cats with glaucoma. Vet Ophthalmol. 2023 Jun 20. doi: 10.1111/vop.13123. Online ahead of print. PMID 37339127
Journal: Veterinary Ophthalmology, Jun 2023
OBJECTIVES To determine the accuracy, precision, and clinical applicability of the ICare® TONOVET Plus (TVP) in cats.
ANIMALS AND PROCEDURES IOP readings obtained with the TVP were compared to values obtained concurrently with the original TONOVET (TV01) and Tono-Pen Vet™ (TP) in 12 normal cats (24 eyes) and 8 glaucomatous LTBP2-mutant cats (13 eyes) in vivo. Reproducibility of TVP readings was also assessed for three observers in the above cats. The anterior chambers of five different normal cat eyes were cannulated ex vivo. IOP was measured with the TVP, TV01, and TP at manometric IOPs ranging from 5 to 70 mmHg. Data were analyzed by linear regression, ANOVA and Bland-Altman plots. ANOVA was used to assess reproducibility of TVP readings obtained by different observers and an ANCOVA model controlled for variation of individual cats. p < .05 was considered significant.
RESULTS TVP values strongly correlated with TV01 values (y = 1.045x + 1.443, R2 = .9667). The TP significantly underestimated IOP relative to the TVP and TV01, particularly at high IOP. IOP values obtained by 1 observer were significantly higher (~1 mmHg average) compared to the other 2 observers via ANCOVA analysis (p = .0006479 and p = .0203). Relative to manometry, the TVP and TV01 were significantly more accurate (p < .0001) and precise (p < .0070) than the TP in ex vivo eyes.
CONCLUSIONS IOP readings obtained with the TVP and TV01 are broadly interchangeable between models and between observers, but subtle differences may be important in a research context. TP readings vastly underestimate high IOP in feline glaucoma.
© 2023 The Authors. Veterinary Ophthalmology published by Wiley Periodicals LLC on behalf of American College of Veterinary Ophthalmologists.