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Gamm Lab

Preventing vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA.

Posted on July 11, 2025

PubMed ID: 40672310 Author(s): Akyuz E, Shahi PK, Gissot L, Al Saneh A, Sinha D, Hanstad GM, Kabra M, Zepeda MAF, Gamm DM, Young SM, Ahern CA, Pattnaik BR. Preventing vision loss in a mouse …

Posted in Bikash Pattnaik, Gamm Lab, Publications

AAV2.7m8 transduction of stage 2 human retinal organoids induces highly variable responses in innate and inflammatory gene expression and cytokine secretion.

Posted on June 6, 2025

PubMed ID: 40484363 Author(s): Sauter MM, Noel HR, Sinha D, Nelson EC, Xiong MN, Gamm DM, Brandt CR. AAV2.7m8 transduction of stage 2 human retinal organoids induces highly variable responses in innate and inflammatory gene …

Posted in Brandt Lab, Gamm Lab, Publications

Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling Nonviral Genome Editing Efficiency.

Posted on March 14, 2025

PubMed ID: 40161775 Author(s): Saxena S, Kabra M, Abdeen A, Sinha D, Zhu M, Xie R, Hanstad G, Zepeda MAF, Gamm DM, Pattnaik BR, Gong S, Saha K. Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling …

Posted in Bikash Pattnaik, Gamm Lab, Publications, Shaoqin Gong

Robust generation of photoreceptor-dominant retinal organoids from porcine induced pluripotent stem cells.

Posted on February 17, 2025

PubMed ID: 40054472 Author(s): Edwards KL, Moore BM, Ganser TS, Susaimanickam PJ, Sovell K, Martin Y, Jager LD, Willes AM, Moyer TH, Bowar L, Phillips MJ, Stewart R, Chu LF, Gamm DM. Robust generation of …

Posted in Gamm Lab, Publications

Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.

Posted on January 1, 2025

PubMed ID: 40554553 Author(s): Wei SC, Cantor AJ, Walleshauser J, Mepani R, Melton K, Bans A, Khekare P, Gupta S, Wang J, Soares C, Kiwan R, Lee J, McCawley S, Jani V, Leong WI, Shahi …

Posted in Bikash Pattnaik, Gamm Lab, Publications

Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.

Posted on December 30, 2024

PubMed ID: 39803585 Author(s): Wei SC, Cantor AJ, Walleshauser J, Mepani R, Melton K, Bans A, Khekare P, Gupta S, Wang J, Soares C, Kiwan R, Lee J, McCawley S, Jani V, Leong WI, Shahi …

Posted in Bikash Pattnaik, Gamm Lab, Publications

Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.

Posted on February 18, 2024

PubMed ID: 37975905 Author(s): Williams BN, Draper A, Lang PF, Lewis TR, Smith AL, Mayerl SJ, Rougie M, Simon JM, Arshavsky VY, Greenwald SH, Gamm DM, Pinilla I, Philpot BD. Heterogeneity in the progression of …

Posted in Gamm Lab, Publications

Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct.

Posted on December 1, 2023

PubMed ID: 37575875 Author(s): Lee IK, Xie R, Luz-Madrigal A, Min S, Zhu J, Jin J, Edwards KL, Phillips MJ, Ludwig AL, Gamm DM, Gong S, Ma Z. Micromolded honeycomb scaffold design to support the …

Posted in Gamm Lab, Publications, Shaoqin Gong

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy.

Posted on October 2, 2023

PubMed ID: 37561581 Author(s): Kabra M, Shahi PK, Wang Y, Sinha D, Spillane A, Newby GA, Saxena S, Tong Y, Chang Y, Abdeen AA, Edwards KL, Theisen CO, Liu DR, Gamm DM, Gong S, Saha …

Posted in Bikash Pattnaik, Gamm Lab, Publications, Shaoqin Gong
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