PubMed ID: 40161775 Author(s): Saxena S, Kabra M, Abdeen A, Sinha D, Zhu M, Xie R, Hanstad G, Zepeda MAF, Gamm DM, Pattnaik BR, Gong S, Saha K. Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling …
Gamm Lab
Robust generation of photoreceptor-dominant retinal organoids from porcine induced pluripotent stem cells.
PubMed ID: 40054472 Author(s): Edwards KL, Moore BM, Ganser TS, Susaimanickam PJ, Sovell K, Martin Y, Jager LD, Willes AM, Moyer TH, Bowar L, Phillips MJ, Stewart R, Chu LF, Gamm DM. Robust generation of …
Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
PubMed ID: 39803585 Author(s): Wei SC, Cantor AJ, Walleshauser J, Mepani R, Melton K, Bans A, Khekare P, Gupta S, Wang J, Soares C, Kiwan R, Lee J, McCawley S, Jani V, Leong WI, Shahi …
Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.
PubMed ID: 37975905 Author(s): Williams BN, Draper A, Lang PF, Lewis TR, Smith AL, Mayerl SJ, Rougie M, Simon JM, Arshavsky VY, Greenwald SH, Gamm DM, Pinilla I, Philpot BD. Heterogeneity in the progression of …
Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct.
PubMed ID: 37575875 Author(s): Lee IK, Xie R, Luz-Madrigal A, Min S, Zhu J, Jin J, Edwards KL, Phillips MJ, Ludwig AL, Gamm DM, Gong S, Ma Z. Micromolded honeycomb scaffold design to support the …
Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy.
PubMed ID: 37561581 Author(s): Kabra M, Shahi PK, Wang Y, Sinha D, Spillane A, Newby GA, Saxena S, Tong Y, Chang Y, Abdeen AA, Edwards KL, Theisen CO, Liu DR, Gamm DM, Gong S, Saha …
UW Researchers Will Develop Gene Editing Therapy to Treat Blindness
A new study by UW researchers will test gene editing therapy to treat blindness. The collaborative project involves a team of ophthalmology researchers and biomedical engineers.
A versatile laser-induced porcine model of outer retinal and choroidal degeneration for preclinical testing.
PubMed ID: 37288665 Author(s): Barone F, Amaral J, Bunea I, Farnoodian M, Gupta R, Gupta R, Baker D, Phillips MJ, Blanch RJ, Maminishkis A, Gamm DM, Bharti K. A versatile laser-induced porcine model of outer …
Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures.
PubMed ID: 36598946 Author(s): Ludwig AL, Mayerl SJ, Gao Y, Banghart M, Bacig C, Fernandez Zepeda MA, Zhao X, Gamm DM. Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures. Proc Natl …