PubMed ID: 41528801 Author(s): Amaral J, Bunea I, Maminishkis A, Campos MM, Barone F, Gupta R, Farnoodian M, Newport J, Phillips MJ, Sharma R, Gamm DM, Bharti K, Blanch RJ. A Porcine Commotio Retinae Model …
Gamm Lab
Monitoring biological effects of somatic cell genome editing.
PubMed ID: 41530266 Author(s): Freedman BS, Bulte JWM, Conklin BR, Judge LM, Dwinell MR, Geurts AM, Sitton MJ, Mahajan V, Kiani S, Gersbach CA, Ebrahimkhani MR, Kelly JJ, Ronald JA, Morizane R, Gupta N, Shakeri-Zadeh …
Preventing vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA.
PubMed ID: 40672310 Author(s): Akyuz E, Shahi PK, Gissot L, Al Saneh A, Sinha D, Hanstad GM, Kabra M, Zepeda MAF, Gamm DM, Young SM, Ahern CA, Pattnaik BR. Preventing vision loss in a mouse …
AAV2.7m8 transduction of stage 2 human retinal organoids induces highly variable responses in innate and inflammatory gene expression and cytokine secretion.
PubMed ID: 40484363 Author(s): Sauter MM, Noel HR, Sinha D, Nelson EC, Xiong MN, Gamm DM, Brandt CR. AAV2.7m8 transduction of stage 2 human retinal organoids induces highly variable responses in innate and inflammatory gene …
Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling Nonviral Genome Editing Efficiency.
PubMed ID: 40161775 Author(s): Saxena S, Kabra M, Abdeen A, Sinha D, Zhu M, Xie R, Hanstad G, Zepeda MAF, Gamm DM, Pattnaik BR, Gong S, Saha K. Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling …
Robust generation of photoreceptor-dominant retinal organoids from porcine induced pluripotent stem cells.
PubMed ID: 40054472 Author(s): Edwards KL, Moore BM, Ganser TS, Susaimanickam PJ, Sovell K, Martin Y, Jager LD, Willes AM, Moyer TH, Bowar L, Phillips MJ, Stewart R, Chu LF, Gamm DM. Robust generation of …
Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
PubMed ID: 40554553 Author(s): Wei SC, Cantor AJ, Walleshauser J, Mepani R, Melton K, Bans A, Khekare P, Gupta S, Wang J, Soares C, Kiwan R, Lee J, McCawley S, Jani V, Leong WI, Shahi …
Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
PubMed ID: 39803585 Author(s): Wei SC, Cantor AJ, Walleshauser J, Mepani R, Melton K, Bans A, Khekare P, Gupta S, Wang J, Soares C, Kiwan R, Lee J, McCawley S, Jani V, Leong WI, Shahi …
Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.
PubMed ID: 37975905 Author(s): Williams BN, Draper A, Lang PF, Lewis TR, Smith AL, Mayerl SJ, Rougie M, Simon JM, Arshavsky VY, Greenwald SH, Gamm DM, Pinilla I, Philpot BD. Heterogeneity in the progression of …