Lab-Grown Retinal Eye Cells Open Door For Clinical Trials to Treat Blindness
Jan 05 2023
Retinal cells grown from stem cells can reach out and connect with neighbors, according to a new study, completing a “handshake” that may show the cells are ready for trials in humans with degenerative eye disorders.
Read MoreCone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.
Mar 03 2022
PubMed ID: 35245468 Author(s): Saha A, Capowski E, Fernandez Zepeda MA, Nelson EC, Gamm DM, Sinha R. Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.…
Read MoreCone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.
Jan 25 2022
PubMed ID: 35104442 Author(s): Saha A, Capowski E, Fernandez Zepeda MA, Nelson EC, Gamm DM, Sinha R. Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.…
Read MoreOuter Retinal Cell Replacement: Putting the Pieces Together.
Aug 12 2021
PubMed ID: 34724034 Author(s): Ludwig AL, Gamm DM. Outer Retinal Cell Replacement: Putting the Pieces Together. Transl Vis Sci Technol. 2021 Aug 12;10(10):15. doi: 10.1167/tvst.10.10.15. PMID 34724034 Journal: Translational Vision Science & Technology, Volume 10,…
Read MoreThe NIH Somatic Cell Genome Editing program.
Apr 01 2021
PubMed ID: 33828315 Author(s): Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac…
Read MoreUltrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction.
Apr 01 2021
PubMed ID: 33883135 Author(s): Lee IK, Ludwig AL, Phillips MJ, Lee J, Xie R, Sajdak BS, Jager LD, Gong S, Gamm DM, Ma Z. Ultrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction. Sci Adv.…
Read MoreCRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids.
Jan 01 2021
PubMed ID: 34869356 Author(s): Wahlin KJ, Cheng J, Jurlina SL, Jones MK, Dash NR, Ogata A, Kibria N, Ray S, Eldred KC, Kim C, Heng JS, Phillips J, Johnston RJ Jr, Gamm DM, Berlinicke C,…
Read MorePAX6D instructs neural retinal specification from human embryonic stem cell-derived neuroectoderm.
Sep 03 2020
PubMed ID: 32700445 Author(s): Tao Y, Cao J, Li M, Hoffmann B, Xu K, Chen J, Lu X, Guo F, Li X, Phillips MJ, Gamm DM, Chen H, Zhang SC. PAX6D instructs neural retinal specification…
Read MoreImaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution.
Aug 11 2020
PubMed ID: 32707075 Author(s): Aboualizadeh E, Phillips MJ, McGregor JE, DiLoreto DA Jr, Strazzeri JM, Dhakal KR, Bateman B, Jager LD, Nilles KL, Stuedemann SA, Ludwig AL, Hunter JJ, Merigan WH, Gamm DM, Williams DR.…
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