PubMed ID: 35245468 Author(s): Saha A, Capowski E, Fernandez Zepeda MA, Nelson EC, Gamm DM, Sinha R. Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea. …
Gamm Lab
Outer Retinal Cell Replacement: Putting the Pieces Together.
PubMed ID: 34724034 Author(s): Ludwig AL, Gamm DM. Outer Retinal Cell Replacement: Putting the Pieces Together. Transl Vis Sci Technol. 2021 Aug 12;10(10):15. doi: 10.1167/tvst.10.10.15. PMID 34724034 Journal: Translational Vision Science & Technology, Volume 10, …
The NIH Somatic Cell Genome Editing program.
PubMed ID: 33828315 Author(s): Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac …
Ultrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction.
PubMed ID: 33883135 Author(s): Lee IK, Ludwig AL, Phillips MJ, Lee J, Xie R, Sajdak BS, Jager LD, Gong S, Gamm DM, Ma Z. Ultrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction. Sci Adv. …
CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids.
PubMed ID: 34869356 Author(s): Wahlin KJ, Cheng J, Jurlina SL, Jones MK, Dash NR, Ogata A, Kibria N, Ray S, Eldred KC, Kim C, Heng JS, Phillips J, Johnston RJ Jr, Gamm DM, Berlinicke C, …
PAX6D instructs neural retinal specification from human embryonic stem cell-derived neuroectoderm.
PubMed ID: 32700445 Author(s): Tao Y, Cao J, Li M, Hoffmann B, Xu K, Chen J, Lu X, Guo F, Li X, Phillips MJ, Gamm DM, Chen H, Zhang SC. PAX6D instructs neural retinal specification …
Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution.
PubMed ID: 32707075 Author(s): Aboualizadeh E, Phillips MJ, McGregor JE, DiLoreto DA Jr, Strazzeri JM, Dhakal KR, Bateman B, Jager LD, Nilles KL, Stuedemann SA, Ludwig AL, Hunter JJ, Merigan WH, Gamm DM, Williams DR. …
Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy.
PubMed ID: 32707085 Author(s): Sinha D, Steyer B, Shahi PK, Mueller KP, Valiauga R, Edwards KL, Bacig C, Steltzer SS, Srinivasan S, Abdeen A, Cory E, Periyasamy V, Siahpirani AF, Stone EM, Tucker BA, Roy …
Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level.
PubMed ID: 32483256 Author(s): Udry F, Decembrini S, Gamm DM, Déglon N, Kostic C, Arsenijevic Y. Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein …