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Nickells Lab

Intravitreal AAV2 gene delivery to feline retinal ganglion cells.

Posted on January 1, 2025

PubMed ID: 39549467 Author(s): Oikawa K, Eaton JS, Kiland JA, Torne O, Mathu V, Nickells RW, McLellan GJ. Intravitreal AAV2 gene delivery to feline retinal ganglion cells. Vision Res. 2025 Jan;226:108519. doi: 10.1016/j.visres.2024.108519. Epub 2024 …

Posted in Gillian McLellan, Nickells Lab, Publications

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations.

Posted on November 4, 2024

PubMed ID: 39560629 Author(s): Muench NA, Schmitt HM, Schlamp CL, Su AA, Washington K, Nickells RW. Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations. Transl Vis Sci Technol. 2024 Nov …

Posted in Nickells Lab, Publications

Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity.

Posted on October 27, 2023

PubMed ID: 37958624 Author(s): Wurl JA, Mac Nair CE, Dietz JA, Shestopalov VI, Nickells RW. Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity. Int J Mol Sci. 2023 Oct …

Posted in Nickells Lab, Publications

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.

Posted on September 26, 2023

PubMed ID: 37752598 Author(s): Maes ME, Donahue RJ, Schlamp CL, Marola OJ, Libby RT, Nickells RW. BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps. Mol Neurodegener. 2023 Sep …

Posted in Nickells Lab, Publications

BclXL (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury.

Posted on July 22, 2022

PubMed ID: 35869049 Author(s): Marola OJ, Yablonski SER, Shrager PG, Nickells RW, Libby RT. BclX(L) (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury. Cell Death Discov. …

Posted in Nickells Lab, Publications

BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma.

Posted on August 10, 2021

PubMed ID: 34376637 Author(s): Donahue RJ, Fehrman RL, Gustafson JR, Nickells RW. BCLX(L) gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma. Cell Death Dis. 2021 Aug 10;12(8):781. doi: 10.1038/s41419-021-04068-x. PMID 34376637 …

Posted in Nickells Lab, Publications

Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression.

Posted on August 2, 2021

PubMed ID: 34398198 Author(s): Schmitt HM, Fehrman RL, Maes ME, Yang H, Guo LW, Schlamp CL, Pelzel HR, Nickells RW. Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression. Invest Ophthalmol Vis …

Posted in Nickells Lab, Publications

The Influence of Mitochondrial Dynamics and Function on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.

Posted on June 25, 2021

PubMed ID: 34201955 Author(s): Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease. Cells. 2021 Jun …

Posted in Nickells Lab, Publications

The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis.

Posted on May 22, 2021

PubMed ID: 34022923 Author(s): Grosser JA, Fehrman RL, Keefe D, Redmon M, Nickells RW. The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis. BMC Res Notes. 2021 May 22;14(1):198. …

Posted in Nickells Lab, Publications
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