PubMed ID: 39549467 Author(s): Oikawa K, Eaton JS, Kiland JA, Torne O, Mathu V, Nickells RW, McLellan GJ. Intravitreal AAV2 gene delivery to feline retinal ganglion cells. Vision Res. 2025 Jan;226:108519. doi: 10.1016/j.visres.2024.108519. Epub 2024 …
Nickells Lab
Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations.
PubMed ID: 39560629 Author(s): Muench NA, Schmitt HM, Schlamp CL, Su AA, Washington K, Nickells RW. Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations. Transl Vis Sci Technol. 2024 Nov …
Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity.
PubMed ID: 37958624 Author(s): Wurl JA, Mac Nair CE, Dietz JA, Shestopalov VI, Nickells RW. Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity. Int J Mol Sci. 2023 Oct …
BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.
PubMed ID: 37752598 Author(s): Maes ME, Donahue RJ, Schlamp CL, Marola OJ, Libby RT, Nickells RW. BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps. Mol Neurodegener. 2023 Sep …
BclXL (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury.
PubMed ID: 35869049 Author(s): Marola OJ, Yablonski SER, Shrager PG, Nickells RW, Libby RT. BclX(L) (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury. Cell Death Discov. …
BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma.
PubMed ID: 34376637 Author(s): Donahue RJ, Fehrman RL, Gustafson JR, Nickells RW. BCLX(L) gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma. Cell Death Dis. 2021 Aug 10;12(8):781. doi: 10.1038/s41419-021-04068-x. PMID 34376637 …
Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression.
PubMed ID: 34398198 Author(s): Schmitt HM, Fehrman RL, Maes ME, Yang H, Guo LW, Schlamp CL, Pelzel HR, Nickells RW. Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression. Invest Ophthalmol Vis …
The Influence of Mitochondrial Dynamics and Function on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.
PubMed ID: 34201955 Author(s): Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease. Cells. 2021 Jun …
The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis.
PubMed ID: 34022923 Author(s): Grosser JA, Fehrman RL, Keefe D, Redmon M, Nickells RW. The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis. BMC Res Notes. 2021 May 22;14(1):198. …