PubMed ID: 37958624 Author(s): Wurl JA, Mac Nair CE, Dietz JA, Shestopalov VI, Nickells RW. Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity. Int J Mol Sci. 2023 Oct …
Nickells Lab
BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.
PubMed ID: 37752598 Author(s): Maes ME, Donahue RJ, Schlamp CL, Marola OJ, Libby RT, Nickells RW. BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps. Mol Neurodegener. 2023 Sep …
BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma.
PubMed ID: 34376637 Author(s): Donahue RJ, Fehrman RL, Gustafson JR, Nickells RW. BCLX(L) gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma. Cell Death Dis. 2021 Aug 10;12(8):781. doi: 10.1038/s41419-021-04068-x. PMID 34376637 …
Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression.
PubMed ID: 34398198 Author(s): Schmitt HM, Fehrman RL, Maes ME, Yang H, Guo LW, Schlamp CL, Pelzel HR, Nickells RW. Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression. Invest Ophthalmol Vis …
The Influence of Mitochondrial Dynamics and Function on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.
PubMed ID: 34201955 Author(s): Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. The Influence of Mitochondrial Dynamics and Function on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease. Cells. 2021 Jun …
The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis.
PubMed ID: 34022923 Author(s): Grosser JA, Fehrman RL, Keefe D, Redmon M, Nickells RW. The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis. BMC Res Notes. 2021 May 22;14(1):198. …
Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis.
PubMed ID: 33426618 Author(s): Grosser JA, Maes ME, Nickells RW. Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis. Apoptosis. 2021 Feb;26(1-2):132-145. doi: 10.1007/s10495-020-01654-w. Epub 2021 Jan 11. PMID 33426618 Journal: Apoptosis : An …
Targeting HDAC3 in the DBA/2J spontaneous mouse model of glaucoma.
PubMed ID: 32971093 Author(s): Schmitt HM, Grosser JA, Schlamp CL, Nickells RW. Targeting HDAC3 in the DBA/2J spontaneous mouse model of glaucoma. Exp Eye Res. 2020 Nov;200:108244. doi: 10.1016/j.exer.2020.108244. Epub 2020 Sep 21. PMID 32971093 …
BAX-Depleted Retinal Ganglion Cells Survive and Become Quiescent Following Optic Nerve Damage.
PubMed ID: 31673950 Author(s): Donahue RJ, Maes ME, Grosser JA, Nickells RW. BAX-depleted retinal ganglion cells survive and become quiescent following optic nerve damage. Mol Neurobiol. 2020 Feb;57(2):1070-1084. doi: 10.1007/s12035-019-01783-7. Epub 2019 Oct 31. PMID …