Yao Liu

Yao Liu, MD, MS

Assistant Professor

Contact Administrative Assistant

I truly enjoy developing relationships over time with my patients, as we work together to improve or maintain their vision.

Specialties:
Adult and pediatric glaucoma, glaucoma and cataract surgery, anterior segment surgery, optic nerve imaging

Fellowship:
Glaucoma, University of California, Davis Eye Center, Sacramento, CA

Residency:
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston

Internship:
Brigham and Women’s Hospital, Harvard Medical School, Boston

Medical School:
Harvard Medical School, Boston

GRANTS AND MONETARY AWARDS


Current 

Agency: NIH/NEI K23 EY026518
Title: Advancing Integration of Tele-ophthalmology for Diabetic Retinopathy in Rural, Multi-payer Settings
Role: Principal Investigator (Mentors: Maureen Smith, Ron Klein, Jane Mahoney)
Percent effort: 75%
Total amount: $811,485
Period: 4/01/16-3/31/21
This study develops an implementation package to facilitate adoption of telemedicine for diabetic retinopathy in rural healthcare settings. Training in health services research includes M.S. in Clinical Investigation. 

Agency: Wisconsin Public Service Commission
Title: Telemedicine Grant, Mile Bluff Medical Center
Role: Collaborator
Percent effort: N/A
Total amount: $55,600
Period: 5/01/18-4/30/19
This funding supports the purchase of 4 non-mydriatic fundus cameras for teleophthalmology at Mile Bluff Medical Center’s Outreach clinics. 

Agency: Lions Eye Bank of Wisconsin Gift of Sight Discovery Fund
Title: Macular Pigment as a Modifiable Glaucoma Risk Factor in Older women
Role: Principal Investigator
Percent effort: 5%
Total amount: $50,000
Period: 1/01/2019-12/31/2019
This is a glaucoma ancillary study to CAREDS2 (R01 EY025292) that will provide the first longitudinal evidence as to whether low macular pigment levels are associated with an increased risk of glaucoma. 

Agency: NIH/NEI R01 EY025292
Title: Macular Pigment in Aging and Disease (CAREDS2)
Role: Co-Investigator (Multiple PIs: Julie Mares, Barbara Blodi)
Percent effort: 5%
Total amount: $1,180,766
Period: 6/01/2015-5/31/2020
This study assesses the relationship between RNFL thickness on spectral domain OCT to macular pigment optical density and risk of macular degeneration in Carotenoids in Age-Related Eye Disease Study (CAREDS). 

Agency: CDC U01 DP006074 (University of Chicago NORC)
Title: Establish a Vision and Eye Health Surveillance System for the Nation
Role: Consultant (PI: David Rein)
Percent effort: N/A
Total amount: $25,000 (subaward)
Period: 10/01/2015-9/30/2019
The purpose of this research is to develop, test, and implement a vision and eye health surveillance system to provide population estimates of vision loss, eye diseases, health disparities, and access to eye care. 

Past Awards 

Agency: American Glaucoma Society Mentoring for Advancement of Physician-Scientists (MAPS) Award
Title: Macular Pigment and Glaucoma Incidence in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2)
Role: Principal Investigator (Mentors: Julie Mares, Thasarat Vajaranant)
Percent effort: N/A
Total amount: $10,000
Period: 1/01/2018-12/31/2018
This is a glaucoma ancillary study to CAREDS2 (R01 EY025292) that will provide the first longitudinal evidence as to whether low macular pigment levels are associated with an increased incidence of glaucoma. 

Agency: Wisconsin Partnership Program New Investigator Program
Title: Advancing Tele-ophthalmology for Diabetic Retinopathy in Rural Wisconsin
Role: Principal Investigator
Percent effort: 5%
Total amount: $100,000
Period: 4/01/16-3/31/18
This study develops an implementation package to facilitate adoption of telemedicine for diabetic retinopathy in rural Wisconsin. 

Agency: NIH/NCATS UL1 TR002373 Univ. of WI ICTR Basic & Clinical Translational Research Pilot Award
Title: Macular Pigment as a Modifiable Glaucoma Risk Factor in Older women
Role: Principal Investigator
Percent effort: 5%
Total amount: $50,000
Period: 6/01/2016-1/31/2018
This is a glaucoma ancillary study to CAREDS2 (R01 EY025292) that will provide the first longitudinal evidence as to whether low macular pigment levels are associated with an increased risk of glaucoma. 

Agency: American Glaucoma Society Mentoring for Advancement of Physician-Scientists (MAPS) Award
Title: Macular pigment levels as a glaucoma risk factor in the Carotenoids in Age-Related Eye Disease Study 2
Role: Principal Investigator (Mentors: Julie Mares, Thasarat Vajaranant)
Percent effort: N/A
Total amount: $10,000
Period: 6/01/2016-5/31/2017
This is a glaucoma ancillary study to CAREDS2 (R01 EY025292) that will provide the first longitudinal evidence as to whether low macular pigment levels are associated with an increased risk of glaucoma. 

Agency: Frederick A. Davis Funds, University of Wisconsin Dept. of Ophthalmology and Visual Sciences
Title: Pilot study to assess the results of multifocal electroretinography (mfERG) and multifocal visual evoked potentials (mfVEP) in patients with glaucoma.
Role: Principal Investigator
Percent effort: N/A
Total amount: $7,000
Period: 10/01/14 – 10/01/18
This study evaluates the use of multifocal electroretinograms and a novel multifocal visual evoked potentials algorithm as objective tests of visual function among patients with glaucoma. 

Agency: Aerie Pharmaceuticals
Title: Aerie Glaucoma Trial – PG324-CS301
Role: Principal Investigator (Site)
Percent effort: N/A
Total amount: $21,125
Period: 7/14/2015-12/31/2017
A randomized, multicenter study assessing the safety and efficacy of PG324 Ophthalmic Solution compared to AR-13324 and Latanoprost Ophthalmic Solution in subjects with elevated intraocular pressure. 

Agency: Bausch and Lomb Inc.
Title: Bausch and Lomb Glaucoma Trial – Protocol 770
Role: Principal Investigator (Site)
Percent effort: N/A
Total amount: $17,057
Period: 5/09/2013-6/1/2015
A randomized, multicenter study comparing the safety and efficacy of BOL-303259-X ophthalmic solution with timolol in subjects with open angle glaucoma or ocular hypertension. 

Publications


Publications in Peer Reviewed Journals 

1. Liu, Y, Carlson, JN, Zupan NJ, Molfenter TD, Mahoney J, Boss D, Klein R, Bjelland TD, Smith MA. Engaging patients and clinical stakeholders to increase teleophthalmology use for diabetic eye screening in rural primary care clinics. Paper in preparation, for submission to Diabetes Care. 

2. Liu Y, Carlson JN, Swearingen R, Georgeson S, Mahoney J, Klein R, Bjelland T, Smith M. Assessing diabetic eye screening rates in a rural, multi-payer health system. Paper in preparation, for submission to BMJ Open Diabetes Research and Care. 

3. Liu Y, Gangaputra S, Jacobson N, Georgeson S, Blodi B, Potter H, Sterken G, Smith M. Patient motivators and preferences regarding diabetic retinopathy screening methods at a rural eye clinic. Paper in preparation, for submission to Telemedicine and e-Health. 

4. Liu Y, Bai M, Blomme C, Mares JA, Vajaranant T; Carotenoids in Age-related Eye Disease Study 2 Writing Group. A Multi-Center, Longitudinal Study of Macular Pigment and Glaucoma Risk: Methods and Utility of RNFL OCT for Identifying Glaucoma. Paper in preparation, for submission to Ophthalmology. 

5. Nguyen L, Kim H, Mielke C, Momont AC, Brandt JD, Liu Y. Combined Ahmed glaucoma implant and dexamethasone intravitreal implant for uveitic glaucoma. Submitted to Journal of Glaucoma. 

6. Liu Y, Diaz Torres A, Benkert R. Scaling up teleophthalmology for diabetic eye screening: opportunities for widespread implementation in the United States. Invited review submitted to Current Diabetes Reports. 

7. Liu Y, Baniasadi N, Ratanawongphaibul K, Chen TC. The effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography (OCT) retinal nerve fiber layer thickness measurement. Submitted to British Journal of Ophthalmology. 

8. Miller N, Liu Y, Krivochenitser R, Rokers B. Linking neural and clinical measures of glaucoma with diffusion magnetic resonance imaging (dMRI). PLoS ONE. 2019; 14(5): e0217011. https://doi.org/10.1371/journal.pone.0217011 

9. Liu Y, Klein BE. The role of statins and cholesterol in primary prevention for primary open angle glaucoma. JAMA Ophthalmology. 2019 May 2. doi: 10.1001/jamaophthalmol.2019.0860. [Epub ahead of print] 

10. Lawler T, Liu Y, Christensen K, Vajaranant TS, Mares JA. Dietary antioxidants, macular pigment, and glaucomatous neurodegeneration: a review of the evidence. Nutrients. 2019, 11, 1002; doi:10.3390/nu11051002 

11. Liu Y, Zupan N, Swearingen R, Jacobson N, Carlson JN, Mahoney J, Klein R, Bjelland T, Smith M. Identification of barriers, facilitators, and system-based implementation strategies to increase teleophthalmology use for diabetic eye screening in a rural U.S. primary care clinic: a qualitative study. BMJ Open. 2019 Feb 18;9(2):e022594. doi: 10.1136/bmjopen-2018-022594. (PMID: 30782868) 

12. Liu Y, Zupan N, Shiyanbola O, Swearingen R, Carlson J, Jacobson N, Mahoney J, Klein R, Bjelland T, Smith M. Factors influencing patient adherence with diabetic eye screening in rural communities: a qualitative study. PLoS ONE. 2018 Nov 2;13(11):e0206742. doi: 10.1371/journal.pone.0206742. (PMID: 30388172) 

13. Liu Y, Loomis S, Parikh R, Kloek CE, Kim LA, Hitchmoth D, Song BJ, Pasquale LR. Diabetic retinopathy assessment variability among eye care providers in an urban teleophthalmology program. Telemedicine and e-Health. 2018 Jul 24. doi: 10.1089/tmj.2018.0019. [Epub ahead of print] (PMID: 30040526) 

14. Rein DB, Wittenborn JS, Phillips EA, Saaddine JB; Vision and Eye Health Surveillance System Study Group. Establishing a vision and eye health surveillance system for the nation: a status update on the vision and eye health surveillance system. Ophthalmology. 2018 Apr;125(4):471-473. doi: 10.1016/j.ophtha.2017.10.014. (PMID: 29566863) 

15. Ye C, Patel CK, Momont AC, Liu Y. Pigment dispersion glaucoma secondary to the Visian phakic intraocular lens. American Journal of Ophthalmology Case Reports. 2018 Feb 1;10:65-67. doi: 10.1016/j.ajoc.2018.01.046. eCollection 2018 Jun. (PMID: 29780917) 

16. Liu Y, Swearingen R. Diabetic eye screening: knowledge and perspectives from providers and patients. Current Diabetes Reports. 2017 Aug 31; 17(10):94. (PMID: 28856510) 

17. Schrieber C, Liu Y. Choroidal effusions after glaucoma surgery. Current Opinion in Ophthalmology. 2015 Mar; 26:135-142. (PMID: 25643198) Video Abstract: http://links.lww.com/COOP/A15 

18. Liu Y, Rhee DJ. Clinical challenge: bilateral acute angle-closure glaucoma. JAMA Ophthalmology. 2013; Sep 131(9):1231-1232. (PMID: 24030335) 

19. Liu Y, Takusagawa HL, Chen TC, Pasquale LR. Fuchs heterochromic iridocyclitis and the rubella virus. International Ophthalmology Clinics. 2011; Fall; 51(4):1-12. (PMID: 21897135) 

20. Takusagawa HL, Liu Y, Wiggs JL. Infectious theories of Posner-Schlossman. International Ophthalmology Clinics. 2011; Fall; 51(4):105-15. (PMID: 21897144) 

21. Gracia-Sancho J, Villarreal G Jr, Zhang Y, Yu JX, Liu Y, Tullius SG, García-Cardeña G. Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention. Transplantation. 2010; Jul 27; 90(2):142-9. (PMID: 20606606) 

22. Liu Y, Dinkin MJ, Loewenstein JI, Rizzo JF III, Cestari DM. Multifocal electroretinogram abnormalities in ethambutol toxicity. J Neuro-ophthalmology 2008; Dec 28(4):278-82. (PMID: 19145124). 

23. Hansen RM, Eklund SE, Benador IY, Mocko JA, Akula JD, Liu Y, Martinez-Perez ME, Fulton AB. Retinal degeneration in children: dark adapted visual threshold and arteriolar diameter. Vision Research. 2008; Feb;48(3):325-31. (PMID: 17765282) 

Publications, Non-Peer Reviewed 

1. Liu Y. Evaluating Glaucoma Progression. Topics in Glaucoma. 2015; Dec; 6:1-4. Continuing Medication Education. University of Florida College of Medicine. 

Other Publications 

1. Telehealth Practice Guidelines for Diabetic Retinopathy. Ocular Telehealth SIG Writing Committee, American Telemedicine Association; 2019 

2. UW Teleophthalmology Program Implementation Toolkit. In preparation for dissemination on HIPxChange (www.hipxchange.org).