Hypoxic-ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina.

Bikash Pattnaik // Gillian McLellan // Publications // Sheibani Lab // Jun 16 2021

PubMed ID: 34135369

Author(s): Zaitoun IS, Shahi PK, Suscha A, Chan K, McLellan GJ, Pattnaik BR, Sorenson CM, Sheibani N. Hypoxic-ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina. Sci Rep. 2021 Jun 16;11(1):12670. doi: 10.1038/s41598-021-90447-5. PMID 34135369

Journal: Scientific Reports, Volume 11, Issue 1, Jun 2021

Ischemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect the susceptibility of and outcome after ischemic stroke. Although we recently reported that exposure of neonatal mice to hypoxia-ischemia (HI) severely compromises the integrity of the retinal neurovasculature, it is not known whether juvenile mice are similarly impacted. Here we examined the effect of HI injury in juvenile mice on retinal structure and function, in particular the susceptibility of retinal neurons and blood vessels to HI damage. Our studies demonstrated that the retina suffered from functional and structural injuries, including reduced b-wave, thinning of the inner retinal layers, macroglial remodeling, and deterioration of the vasculature. The degeneration of the retinal vasculature associated with HI resulted in a significant decrease in the numbers of pericytes and endothelial cells as well as an increase in capillary loss. Taken together, these findings suggest a need for juveniles suffering from ischemic stroke to be monitored for changes in retinal functional and structural integrity. Thus, there is an emergent need for developing therapeutic approaches to prevent and reverse retinal neurovascular dysfunction with exposure to ischemic stroke.