PubMed ID: 191424
Author(s): Albert DM, Lahav M, Colby ED, Shadduck JA, Sang DN. Retinal neoplasia and dysplasia. I. Induction by feline leukemia virus. Invest Ophthalmol Vis Sci. 1977 Apr;16(4):325-37. PMID 191424
Journal: Investigative Ophthalmology & Visual Science, Volume 16, Issue 4, Apr 1977
Feline leukemia virus, a naturally occurring C-type virus (oncorna virus), was injected systemically and intraocularly into fetal and newborn kittens. A light microscopy study of the resultant ocular tumor changes was carried out. One animal developed an intraocular tumor of apparent retinal origin. Eight animals showed intraocular neoplastic cell infiltration. The most common ocular change observed was retinal dysplasia. Sequential histologic examination of enucleated eyes showed diffuse intraocular inflammation after viral inoculation. In the developing retinas progressive disorganization and necrosis were documented, with subsequent reorganization into cell clumps and dysplastic rosette structures. The retinal pigment epithelium showed proliferation and intraretinal migration. The mature retina exhibited full-thickness folds and tubes associated with infoldings of the retinal pigment epithelium.