Topical therapeutic efficacy of 9-(2-hydroxyethoxymethyl)guanine and 5-iodo-5′-amino-2′,5′-dideoxyuridine on oral infection with herpes simplex virus in mice.

Daniel Albert // Publications // May 01 1980

PubMed ID: 6966305

Author(s): Park NH, Pavan-Langston D, Hettinger ME, McLean SL, Albert DM, Lin TS, Prusoff WH. Topical therapeutic efficacy of 9-(2-hydroxyethoxymethyl)guanine and 5-iodo-5′-amino-2′,5′-dideoxyuridine on oral infection with herpes simplex virus in mice. J Infect Dis. 1980 May;141(5):575-9. PMID 6966305

Journal: The Journal Of Infectious Diseases, Volume 141, Issue 5, May 1980

The therapeutic efficacy of two new antiviral agents, 5-iodo-5′-amino-2′, 5′-dideoxyuridine (AIdUrd) and 9-(2-hydroxyethoxymethyl)guanine (ACV), in the model of mouse lip inoculated with herpes simplex virus type 2 is reported. The effects on development of clinical lesions, viral replication in the inoculated lips, and establishment of latent viral infection in the trigeminal ganglia were observed. The earlier the treatment with AIdUrd and ACV was initiated after inoculation, the better was the chemotherapeutic effect. AIdUrd and ACV treatment, when initiated 48 and 72 hr after inoculation, respectively, showed no chemotherapeutic efficacy. Establishment of viral latent infection in sensory ganglia was significantly prevented only when ACV treatment was initiated very early (1 or 3 hr) after inoculation. The results indicate that both drugs have significant antiviral activity, in part dependent on the time of initiation of therapy, and that ACV is superior to AIdUrd as a topical agent for therapy of herpes simplex virus type 2 infections.