An in vitro investigation of x-ray sensitivity in fibroblasts from patients with retinoblastoma.

Publications // Jul 01 1983

PubMed ID: 6862797

Author(s): Weichselbaum R, Albert DM, Cassady JR, Little JB. An in vitro investigation of x-ray sensitivity in fibroblasts from patients with retinoblastoma. Invest Ophthalmol Vis Sci. 1983 Jul;24(7):958-61.

Journal: Investigative Ophthalmology & Visual Science, Volume 24, Issue 7, Jul 1983

In vitro x-ray survival experiments were performed on fibroblast strains derived from nine patients with sporadic unilateral retinoblastoma, 26 patients with hereditary retinoblastoma, and six normal controls. The x-ray sensitivity of the strains derived from the sporadic retinoblastoma patients and normal controls did not significantly differ from one another. The fibroblast strains derived from patients with hereditary retinoblastoma were significantly more radiosensitive to killing by x-rays as measured by clonogenic survival than either the sporadic strains or the strains derived from normal controls. We hypothesize that the increased in vitro radiosensitivity observed in some hereditary retinoblastoma strains is a reflection of an as yet uncharacterized defect in DNA or DNA replication postirradiation.