Endothelin-1 effects on aqueous humor dynamics in monkeys.

Kaufman Lab // Publications // Dec 01 1998

PubMed ID: 9881547

Author(s): Millar JC, Gabelt BT, Hubbard WC, Kiland JA, Kaufman PL. Endothelin-1 effects on aqueous humor dynamics in monkeys. Acta Ophthalmol Scand. 1998 Dec;76(6):663-7. PMID 9881547

Journal: Acta Ophthalmologica Scandinavica, Volume 76, Issue 6, Dec 1998

PURPOSE To report data showing no effect of endothelin-1 on aqueous humor formation and total outflow facility in the cynomolgus monkey, in contrast to the enhancement of outflow facility in monkeys and the suppression of aqueous humor flow in rabbits previously reported by others.

METHODS Living monkeys received, unilaterally: (i) intracameral endothelin-1 (10 microl bolus, or 2ml or 4ml exchange; final intracameral concentration 1 or 10 nM) with total outflow facility measured for up to 1 hr post-treatment by two-level constant pressure perfusion, and (ii) intravitreal endothelin-1 (20 microl, final intravitreal concentration 0.1 or 1 microM) with aqueous humor flow measured by scanning fluorophotometry for 5 hr starting 12 hr post-treatment. Contralateral eyes received vehicle.

RESULTS Endothelin-1 had no effect on total outflow facility or aqueous humor flow with any of the methods described.

CONCLUSION Endothelin-1 seems have a variable effect on aqueous humor dynamics within and between species.