Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes?

Kleins Lab // Publications // Mar 01 2006

PubMed ID: 16488949

Author(s): Wong TY, Mohamed Q, Klein R, Couper DJ. Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes? Br J Ophthalmol. 2006 Mar;90(3):301-3. PMID 16488949

Journal: The British Journal Of Ophthalmology, Volume 90, Issue 3, Mar 2006

BACKGROUND/AIMS Isolated retinopathy signs are common in non-diabetic individuals and have been shown to be associated with impaired glucose metabolism. In a cohort of people without diabetes, the association of these retinopathy signs and subsequent development of diabetes were examined.

METHODS A population based cohort study of 7992 people aged 49-73 years without diabetes was conducted. Retinal photographs of these participants were evaluated for the presence of retinopathy signs according to a standardised protocol. Incident cases of diabetes were identified prospectively.

RESULTS After a follow up of 3 years, 291 (3.6%) people developed incident diabetes. In the total cohort, retinopathy was not significantly associated with incident diabetes (4.7% v 3.6%, multivariable adjusted odds ratio (OR) 1.1, 95% confidence intervals (CI), 0.7 to 1.9). However, among participants with a positive family history of diabetes, retinopathy was associated with incident diabetes (10.4% v 4.8%, multivariable adjusted OR 2.3, 95% CI, 1.0 to 5.3). Among participants without a family history of diabetes, retinopathy was not associated with incident diabetes

CONCLUSIONS In individuals with a family history of diabetes, retinopathy signs predict subsequent risk of clinical diabetes.