Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities study.

Kleins Lab // Publications // Jan 01 2007

PubMed ID: 17188055

Author(s): Grosso A, Mosley TH, Klein R, Couper DJ, Tikellis G, Wong TY; Atherosclerosis Risk in Communities Study. Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities Study. Am J Ophthalmol. 2007 Jan;143(1):157-9. Epub 2006 Aug 31. PMID 17188055

Journal: American Journal Of Ophthalmology, Volume 143, Issue 1, Jan 2007

PURPOSE To examine the relation of early age-related macular degeneration (AMD) with cerebral magnetic resonance imaging (MRI) changes.

DESIGN Population-based, cross-sectional study.

METHODS A sample of 1,684 persons ages 51 to 72 years with no history of stroke had cerebral MRI and retinal photography. MRI scans were graded for severity of white matter lesions (WML), sulcal widening (SW), and ventricular enlargement (VE). AMD was graded from retinal photographs.

RESULTS After adjustment for age, gender, race, or center, early AMD (5.0% of participants) was not significantly associated with WML (odds ratio [OR] 1.0, 95% confidence intervals [CI], 0.6 to 1.6), SW (OR 0.6, 95% CI, 0.4 to 1.2), or VE (OR 1.0, 95% CI, 0.6 to 1.8).

CONCLUSIONS These data showed no statistically significant association of early AMD with cerebral MRI changes, but the study was limited by a small number of cases with wide CIs. Further studies may clarify these associations.