PubMed ID: 37440013
Author(s): Mowat FM. Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1Alpha (PGC-1alpha): A Transcriptional Regulator at the Interface of Aging and Age-Related Macular Degeneration? Adv Exp Med Biol. 2023;1415:49-53. doi: 10.1007/978-3-031-27681-1_8. PMID 37440013
Journal: Advances In Experimental Medicine And Biology, Volume 1415, 2023
Human age-related macular degeneration (AMD) is a prevalent age-related disease which causes retinal dysfunction and disability. Genetic and cell culture studies from AMD patients have implicated impaired activity of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α). PGC-1α is a transcriptional co-regulator that acts to control a plethora of metabolic processes relevant to AMD pathophysiology including gluconeogenesis, oxidative phosphorylation, and response to oxidative injury. Perturbation of PGC-1α activity in mice causes AMD-like RPE and retinal pathology. There is potential for therapeutic modulation of the PGC-1α pathway in AMD treatment.
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.