Cross-Linked actin networks (CLANs) and their role in the trabecular meshwork.

PubMed ID: 42061598

Author(s): Huang A, Dalloul JM, Sugali CK, Dhamodaran K, Dai J, Rai A, McLellan GJ, Mao W. Cross-Linked actin networks (CLANs) and their role in the trabecular meshwork. Exp Eye Res. 2026 Apr 28:111040. doi: 10.1016/j.exer.2026.111040. Online ahead of print. PMID 42061598

Journal: Experimental Eye Research, Apr 2026

Glaucoma is a leading cause of irreversible blindness worldwide, characterized by progressive optic neuropathy commonly associated with elevated intraocular pressure (IOP). The trabecular meshwork (TM) is a critical regulator of aqueous humor outflow, and its biological and biomechanical properties directly influence IOP homeostasis. In glaucomatous eyes and in response to various glaucomatous stimuli, TM cells form cross-linked actin networks (CLANs), a special geodesic actin structure. CLANs alter cytoskeletal dynamics, increase cell stiffness, and impair TM function. This review summarizes past and recent research of CLANs, including their inducers, effects on the TM, and role in glaucoma pathogenesis, as well as suggests some future research directions.