PubMed ID: 34612139 Author(s): Shankar SP, Fallurin R, Watson T, Shankar PR, Young TL, Orel-Bixler D, Rauen KA. Ophthalmic manifestations in Costello syndrome caused by RAS pathway dysregulation during development. Ophthalmic Genet. 2022 Feb;43(1):48-57. doi: …
Young Lab
Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies.
PubMed ID: 34663817 Author(s): Thomson BR, Liu P, Onay T, Du J, Tompson SW, Misener S, Purohit RR, Young TL, Jin J, Quaggin SE. Cellular crosstalk regulates the aqueous humor outflow pathway and provides new …
Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia.
PubMed ID: 34698770 Author(s): Plotnikov D, Cui J, Clark R, Wedenoja J, Pärssinen O, Tideman JWL, Jonas JB, Wang Y, Rudan I, Young TL, Mackey DA, Terry L, Williams C, Guggenheim JA; UK Biobank Eye …
Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia.
PubMed ID: 33830181 Author(s): Tideman JWL, Pärssinen O, Haarman AEG, Khawaja AP, Wedenoja J, Williams KM, Biino G, Ding X, Kähönen M, Lehtimäki T, Raitakari OT, Cheng CY, Jonas JB, Young TL, Bailey-Wilson JE, Rahi …
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.
PubMed ID: 33627673 Author(s): Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segrè AV, Rouhana JM, Hamel AR, Igo RP Jr, Choquet H, Qassim A, Josyula NS, …
MYOPIA
To identify genes that are involved in eye growth specifically in individuals and families with nearsightedness (myopia).
GENETIC EYE DISORDERS
To identify the gene or genes responsible for developmental causes of blindness in the world, and to establish a Pediatric Ophthalmic Genetics and Research Program at the University of Wisconsin–Madison.
SVEP1 as a Genetic Modifier of TEK-Related Primary Congenital Glaucoma.
PubMed ID: 33027505 Author(s): Young TL, Whisenhunt KN, Jin J, LaMartina SM, Martin SM, Souma T, Limviphuvadh V, Suri F, Souzeau E, Zhang X, Dan Y, Anagnos E, Carmona S, Jody NM, Stangel N, Higuchi …
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.
PubMed ID: 32193507 Author(s): Fan Q, Pozarickij A, Tan NYQ, Guo X, Verhoeven VJM, Vitart V, Guggenheim JA, Miyake M, Tideman JWL, Khawaja AP, Zhang L, MacGregor S, Höhn R, Chen P, Biino G, Wedenoja …