Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.

Publications // Young Lab // Jul 01 2016

PubMed ID: 27409473

Author(s): Kuo AN, Verkicharla PK, McNabb RP, Cheung CY, Hilal S, Farsiu S, Chen C, Wong TY, Ikram MK, Cheng CY, Young TL, Saw SM, Izatt JA. Posterior eye shape measurement with retinal OCT compared to MRI. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT196-203. doi: 10.1167/iovs.15-18886. PMID 27409473

Journal: Investigative Ophthalmology & Visual Science, Volume 57, Issue 9, Jul 2016

PURPOSE Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI.

METHODS Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical coherence tomography segmentations were corrected for optical and display distortions requiring biometry data. The segmentations were fitted to spheres and ellipsoids to obtain the posterior eye radius of curvature (Rc) and asphericity (Qxz). The differences in Rc and Qxz measured by MRI and OCT were tested using paired t-tests. Categorical assignments of prolateness or oblateness using Qxz were compared.

RESULTS Fifty-two subjects (67.8 ± 5.6 years old) with spherical equivalent refraction from +0.50 to -5.38 were included. The mean paired difference between MRI and original OCT posterior eye Rc was 24.03 ± 46.49 mm (P = 0.0005). For corrected OCT images, the difference in Rc decreased to -0.23 ± 2.47 mm (P = 0.51). The difference between MRI and OCT asphericity, Qxz, was -0.052 ± 0.343 (P = 0.28). However, categorical agreement was only moderate (κ = 0.50).

CONCLUSIONS Distortion-corrected OCT measurements of Rc and Qxz were not statistically significantly different from MRI, although the moderate categorical agreement suggests that individual differences remained. This study provides evidence that with distortion correction, noninvasive office-based OCT could potentially be used instead of MRI for the study of posterior eye shape.