Comprehensive Analysis of Pathogens, Resistomes, and Inflammatory- markers in the Cornea

  • Sponsor: University of California San Francisco
  • Principal Investigator: Sarah Nehls, MD
  • Study Coordinator: Chris Smith

Study Objective:

To identify pathogens causing infectious keratitis in an unbiased manner with metagenomic deep sequencing (MDS) and determine optimal diagnostic technique for corneal ulcers.

Study Design:

Patients will provide a corneal/conjunctival sample that will be sent for molecular analysis. Patients will have one follow-up visit 4 weeks after sample collection.

Inclusion Criteria:

  • Presence of corneal ulcer: defined as corneal epithelial defect with underlying corneal infiltrate and signs of acute inflammation
  • All ages excluding neonates (˂1-month-old)

Exclusion Criteria:

  • Corneal perforation
  • Inability to give consent

Contact Chris Smith with questions, 608-263-7169