Clinical Trials

Age-Related Macular Degeneration

Status: Active: Recruiting

ARIS

Age-Related Macular Degeneration Ryan Initiative Study (ARIS). Enhancing the understanding of the natural history of early AMD and RPD.

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Status: Active: Recruiting

GALLEGO/GALLEGOLE

A Phase II, Multicenter, Randomized, Single-Masked, Sham-Controlled Study to Assess Safety, Tolerability, and Efficacy of Intravitreal Injections of FHTR2163 in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration (GALLEGO)

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Status: Active: Recruiting

PEP

Patient Experience and Preference (PEP) Study in nAMD and DME

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Status: Active: Recruiting

ATMOSPHERE

A Randomized, Partially Masked, Controlled, Phase 2b/3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with nAMD (ATMOSPHERE)

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Status: Active: Enrollment Closed

OAKS/GALE

A Phase III, Multi-Center, Randomized, Double-Masked, Sham Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) (OAKS)

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Status: Active: Enrollment Closed

DERBY/GALE

A Phase III, Multi-Center, Randomized, Double-Masked, Sham Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) (DERBY)

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Status: Active: Enrollment Closed

PULSAR

Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients with Neovascular Age-Related Macular Degeneration (PULSAR)

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Status: Active: Enrollment Closed

BIM2

To identify whether genetic variation or polymorphism in genes that impact angiogenesis can be identified as biomarkers for responsiveness to anti-VEGF therapy in patients with neovascular age-related macular degeneration.

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Choroidal Melanoma

Status: Active: Recruiting

AURA

A Phase 2 Trial of AU-011 Via Suprachoroidal Administration with a Dose Escalation Phase (Open-label, Ascending Single and Repeat Dose) and a Randomized, Masked Dose Expansion Phase Designed to Evaluate the Safety and Efficacy of AU-011 in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma

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Cornea

Status: Active: Recruiting

Zoster Eye Disease Study (ZEDS)

A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Suppressive Valacyclovir for One Year in Immunocompetent Study Participants with an Episode of Dendriform Epithelial Keratitis, Stromal Keratitis, Endothelial Keratitis, and/or Iritis Due to Herpes Zoster Ophthalmicus (HZO) in the Year Prior to Enrollment (ZEDS)

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Status: Active: Recruiting

oGVHD

Scleral Contact Lens Reduction of Dry Eye Inflammation in Patients with Graft-Versus-Host Disease (GVHD)

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Diabetic Macular Edema

Status: Active: Recruiting

PEP

Patient Experience and Preference (PEP) Study in nAMD and DME

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Status: Active: Recruiting

UNITY

A Phase 2a, Prospective, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Safety, Tolerability and Evidence of Activity of a Single Intravitreal Injection of UBX1325 in Patients with Diabetic Macular Edema

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Status: Active: Enrollment Closed

YOSEMITE/RHONE-X

A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients with Diabetic Macular Edema (YOSEMITE)

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Status: Active: Enrollment Closed

KESTREL

A Two-year, Three-arm, Randomized, Double-masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Adult Patients with Visual Impairment Due to Diabetic Macular Edema (KESTREL)

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Genetics

Status: Active: Recruiting

GENETIC EYE DISORDERS

To identify the gene or genes responsible for developmental causes of blindness in the world, and to establish a Pediatric Ophthalmic Genetics and Research Program at the University of Wisconsin – Madison.

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Status: Active: Recruiting

MYOPIA

To identify genes that are involved in eye growth specifically in individuals and families with nearsightedness (myopia).

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Inherited Retinal Diseases

Status: Active: Recruiting

SOLSTICE

A Long-term Follow-up Study to Evaluate the Safety and Efficacy of Retinal Gene Therapy in Subjects with Choroideremia Treated Previously with Adeno-Associated Viral Vector Encoding Rab Escort Protein-1 (AAV2-REP1) in an Antecedent Study (SOLSTICE)

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Status: Active: Recruiting

AGTC B3

A Multiple-Site, Phase 1/2, Safety and Efficacy Trial of a Recombinant Adeno-associated Virus Vector Expressing CNGB3 (rAAV2tYF-PR1.7-hCNGB3) in Patients with Congenital Achromatopsia Caused by Mutations in the CNGB3 Gene

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Status: Active: Recruiting

AGTC A3

A Multiple-Site, Phase 1/2, Safety and Efficacy Trial of AGTC 402, a Recombinant Adeno-associated Virus Vector Expressing CNGA3, in Patients with Congenital Achromatopsia Caused by Mutations in the CNGA3 Gene

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Status: Active: Recruiting

Pro-EYS

Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS).

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Status: Active: Recruiting

XOLARIS

To gain a better understanding of disease progression over time in male subjects with X-linked retinitis pigmentosa (XLRP).

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Status: Active: Enrollment Closed

CHM SURVEY TRIAL

To assess health-related quality of life, health utility, work productivity, and impact on daily activities in patients/caregivers with CHM at different stages of disease progression.

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Other Explorations

Status: Active: Enrollment Closed

PRIM

To determine risk factors, prevalence, and incidence of maculopathy in UW patients with interstitial cystitis on pentosan polysulfate (PPS).

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Pediatrics

Status: Active: Recruiting

AS OCT2

To investigate whether anatomical differences in Schlemm’s canal and anterior segment structures are associated with the development of glaucoma in pediatric patients that undergo cataract surgery.

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Status: Active: Recruiting

CLN-0500

A Randomized, Parallel-Arm, Active Control, Multicenter Study Assessing the Safety and Efficacy of Dextenza for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract

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Status: Active: Enrollment Closed

INTERMITTENT EXOTROPIA STUDY (IXT1)

A Randomized Trial of Bilateral Lateral Rectus Recession versus Unilateral Lateral Rectus Recession with Medial Rectus Resection for Intermittent Exotropia

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Status: Active: Enrollment Closed

CHAMP

A 3-Arm Randomized, Double-Masked, Placebo-Controlled, Phase 3 Study of NVK-002 in Children with Myopia (CHAMP)

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Retinal Vein Occlusion

Status: Active: Enrollment Closed

RAPTOR

An Eighteen-Month, Two-Arm, Randomized, Double Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Adult Patients with Visual Impairment Due to Macular Edema Secondary to Branch Retinal Vein Occlusion (RAPTOR)

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Status: Active: Enrollment Closed

RAVEN

An Eighteen-Month, Two-Arm, Randomized, Double Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Adult Patients with Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion

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Uveitis

Status: Active: Recruiting

LUMINA

A Phase III, Multicenter, Sham-Controlled, Randomized, Double-Masked Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye (LUMINA)

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Status: Active: Recruiting

MICROBIOME

To compare the gut microbiota composition in pediatric Juvenile Idiopathic Arthritis (JIA) uveitis patients to JIA patients without uveitis and to healthy controls.

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