Clinical Trials

Age-Related Macular Degeneration

Status: Active: Recruiting

ATMOSPHERE

A Randomized, Partially Masked, Controlled, Phase 2b/3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with nAMD (ATMOSPHERE)

Status: Active: Recruiting

HONU

The purpose of this study is to assess iAMD disease progression, by the timeline and rates of conversion for high-risk iAMD at baseline to more advanced AMD stages.

Status: Active: Recruiting

CONCERTO

To determine the safety and effectiveness of the smaller incision, new generation (SING), implantable miniature telescope (IMT) in patients with moderate-severe central vision loss due to late-stage age-related macular degeneration (AMD).

Status: Active: Enrollment Closed

PULSAR

Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients with Neovascular Age-Related Macular Degeneration (PULSAR)

Status: Active: Enrollment Closed

GALE

To assess the long-term efficacy and safety of multiple intravitreal injections of APL-2 in subjects with geographic atrophy secondary to age-related macular degeneration.

Choroidal Melanoma

Status: Active: Enrollment Closed

AURA

A Phase 2 Trial of AU-011 Via Suprachoroidal Administration with a Dose Escalation Phase (Open-label, Ascending Single and Repeat Dose) and a Randomized, Masked Dose Expansion Phase Designed to Evaluate the Safety and Efficacy of AU-011 in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma

Cornea

Status: Active: Recruiting

CORNEA

Scleral Contact Lens Reduction of Dry Eye Inflammation in Patients with Graft-Versus-Host Disease (GVHD)

Status: Active: Recruiting

RECORDATI MT8

Efficacy, Safety and Pharmacokinetics of 3 Doses of REC 0/0559 Eye Drops (MT8) for the Treatment of Stage 2 (Moderate) and 3 (Severe) Neurotrophic Keratitis in Adult Patients

Status: Active: Recruiting

CapriCORN

Comprehensive Analysis of Pathogens, Resistomes, and Inflammatory-markers in the Cornea

Status: Active: Enrollment Closed

Zoster Eye Disease Study (ZEDS)

A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Suppressive Valacyclovir for One Year in Immunocompetent Study Participants with an Episode of Dendriform Epithelial Keratitis, Stromal Keratitis, Endothelial Keratitis, and/or Iritis Due to Herpes Zoster Ophthalmicus (HZO) in the Year Prior to Enrollment (ZEDS)

Diabetic Macular Edema

Status: Active: Enrollment Closed

YOSEMITE/RHONE-X

A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients with Diabetic Macular Edema (YOSEMITE)

Genetics

Status: Active: Recruiting

GENETIC EYE DISORDERS

To identify the gene or genes responsible for developmental causes of blindness in the world, and to establish a Pediatric Ophthalmic Genetics and Research Program at the University of Wisconsin – Madison.

Status: Active: Recruiting

MYOPIA

To identify genes that are involved in eye growth specifically in individuals and families with nearsightedness (myopia).

Glaucoma

Status: Active: Recruiting

COAST

Clarifying the Optimal Application of SLT Therapy Trial (COAST)

Inherited Retinal Diseases

Status: Active: Enrollment Closed

SOLSTICE

A Long-term Follow-up Study to Evaluate the Safety and Efficacy of Retinal Gene Therapy in Subjects with Choroideremia Treated Previously with Adeno-Associated Viral Vector Encoding Rab Escort Protein-1 (AAV2-REP1) in an Antecedent Study (SOLSTICE)

Status: Active: Enrollment Closed

Pro-EYS

Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS).

Oculoplastics

Status: Active: Recruiting

TED

A Phase 2b, Randomized, Double-Mask, Placebo-Controlled, Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Linsitinib in Subjects with Active, Moderate to Severe Thyroid Eye Disease (TED)

Status: Active: Recruiting

IMVT TED

A Phase 3, Multi-center, Randomized, Quadruple-masked, Placebo-controlled Study of Batoclimab for the Treatment of Participants with Active Thyroid Eye Disease (TED)

Pediatrics

Status: Active: Enrollment Closed

CHAMP

A 3-Arm Randomized, Double-Masked, Placebo-Controlled, Phase 3 Study of NVK-002 in Children with Myopia (CHAMP)

Status: Active: Enrollment Closed

AS OCT2

To investigate whether anatomical differences in Schlemm’s canal and anterior segment structures are associated with the development of glaucoma in pediatric patients that undergo cataract surgery.

Uveitis

Status: Active: Recruiting

MICROBIOME

To compare the gut microbiota composition in pediatric Juvenile Idiopathic Arthritis (JIA) uveitis patients to JIA patients without uveitis and to healthy controls.

Status: Active: Recruiting

IZOKIBEP (IL-17A)

To assess the safety, tolerability, and immunogenicity of izokibep in subjects with active non-infectious, intermediate-, posterior- or pan-uveitis requiring high-dose steroids.

Status: Active: Recruiting

SANDCAT

A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Investigate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of RO7200220 Administered Intravitreally in Patients with Uveitic Macular Edema (Sandcat)