Age-Related Macular Degeneration
Status: Active: Recruiting
ARIS
Age-Related Macular Degeneration Ryan Initiative Study (ARIS). Enhancing the understanding of the natural history of early AMD and RPD.
Read MoreStatus: Active: Recruiting
GALLEGO/GALLEGOLE
A Phase II, Multicenter, Randomized, Single-Masked, Sham-Controlled Study to Assess Safety, Tolerability, and Efficacy of Intravitreal Injections of FHTR2163 in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration (GALLEGO)
Read MoreStatus: Active: Recruiting
ATMOSPHERE
A Randomized, Partially Masked, Controlled, Phase 2b/3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with nAMD (ATMOSPHERE)
Read MoreStatus: Active: Enrollment Closed
OAKS/GALE
A Phase III, Multi-Center, Randomized, Double-Masked, Sham Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) (OAKS)
Read MoreStatus: Active: Enrollment Closed
DERBY/GALE
A Phase III, Multi-Center, Randomized, Double-Masked, Sham Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) (DERBY)
Read MoreStatus: Active: Enrollment Closed
PULSAR
Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients with Neovascular Age-Related Macular Degeneration (PULSAR)
Read MoreChoroidal Melanoma
Status: Active: Recruiting
AURA
A Phase 2 Trial of AU-011 Via Suprachoroidal Administration with a Dose Escalation Phase (Open-label, Ascending Single and Repeat Dose) and a Randomized, Masked Dose Expansion Phase Designed to Evaluate the Safety and Efficacy of AU-011 in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma
Read MoreCornea
Status: Active: Recruiting
Zoster Eye Disease Study (ZEDS)
A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Suppressive Valacyclovir for One Year in Immunocompetent Study Participants with an Episode of Dendriform Epithelial Keratitis, Stromal Keratitis, Endothelial Keratitis, and/or Iritis Due to Herpes Zoster Ophthalmicus (HZO) in the Year Prior to Enrollment (ZEDS)
Read MoreStatus: Active: Recruiting
oGVHD
Scleral Contact Lens Reduction of Dry Eye Inflammation in Patients with Graft-Versus-Host Disease (GVHD)
Read MoreDiabetic Macular Edema
Status: Active: Recruiting
UNITY
A Phase 2a, Prospective, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Safety, Tolerability and Evidence of Activity of a Single Intravitreal Injection of UBX1325 in Patients with Diabetic Macular Edema
Read MoreStatus: Active: Enrollment Closed
YOSEMITE/RHONE-X
A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients with Diabetic Macular Edema (YOSEMITE)
Read MoreGenetics
Status: Active: Recruiting
GENETIC EYE DISORDERS
To identify the gene or genes responsible for developmental causes of blindness in the world, and to establish a Pediatric Ophthalmic Genetics and Research Program at the University of Wisconsin – Madison.
Read MoreStatus: Active: Recruiting
MYOPIA
To identify genes that are involved in eye growth specifically in individuals and families with nearsightedness (myopia).
Read MoreGlaucoma
Status: Active: Recruiting
COAST
Clarifying the Optimal Application of SLT Therapy Trial (COAST)
Read MoreInherited Retinal Diseases
Status: Active: Recruiting
SOLSTICE
A Long-term Follow-up Study to Evaluate the Safety and Efficacy of Retinal Gene Therapy in Subjects with Choroideremia Treated Previously with Adeno-Associated Viral Vector Encoding Rab Escort Protein-1 (AAV2-REP1) in an Antecedent Study (SOLSTICE)
Read MoreStatus: Active: Recruiting
Pro-EYS
Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS).
Read MoreStatus: Active: Recruiting
XOLARIS
To gain a better understanding of disease progression over time in male subjects with X-linked retinitis pigmentosa (XLRP).
Read MoreStatus: Active: Recruiting
SIRIUS
A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety, and Tolerability of QR-421a in Subjects with Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene with Advanced Vision Loss (SIRIUS).
Read MoreStatus: Active: Recruiting
CELESTE
A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety, and Tolerability of QR-421a in Subjects with Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene with Early to Moderate Vision Loss (CELESTE)
Read MoreOther Explorations
Status: Active: Enrollment Closed
PRIM
To determine risk factors, prevalence, and incidence of maculopathy in UW patients with interstitial cystitis on pentosan polysulfate (PPS).
Read MorePediatrics
Status: Active: Recruiting
AS OCT2
To investigate whether anatomical differences in Schlemm’s canal and anterior segment structures are associated with the development of glaucoma in pediatric patients that undergo cataract surgery.
Read MoreStatus: Active: Recruiting
CLN-0500
A Randomized, Parallel-Arm, Active Control, Multicenter Study Assessing the Safety and Efficacy of Dextenza for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract
Read MoreStatus: Active: Enrollment Closed
INTERMITTENT EXOTROPIA STUDY (IXT1)
A Randomized Trial of Bilateral Lateral Rectus Recession versus Unilateral Lateral Rectus Recession with Medial Rectus Resection for Intermittent Exotropia
Read MoreStatus: Active: Enrollment Closed
CHAMP
A 3-Arm Randomized, Double-Masked, Placebo-Controlled, Phase 3 Study of NVK-002 in Children with Myopia (CHAMP)
Read MoreRetinal Vein Occlusion
Uveitis
Status: Active: Recruiting
LUMINA
A Phase III, Multicenter, Sham-Controlled, Randomized, Double-Masked Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye (LUMINA)
Read MoreStatus: Active: Recruiting
MICROBIOME
To compare the gut microbiota composition in pediatric Juvenile Idiopathic Arthritis (JIA) uveitis patients to JIA patients without uveitis and to healthy controls.
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