Age-Related Macular Degeneration
Status: Active: Recruiting
ARIS
Age-Related Macular Degeneration Ryan Initiative Study (ARIS). Enhancing the understanding of the natural history of early AMD and RPD.
Read MoreStatus: Active: Recruiting
GALLEGO/GALLEGOLE
A Phase II, Multicenter, Randomized, Single-Masked, Sham-Controlled Study to Assess Safety, Tolerability, and Efficacy of Intravitreal Injections of FHTR2163 in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration (GALLEGO)
Read MoreStatus: Active: Recruiting
ATMOSPHERE
A Randomized, Partially Masked, Controlled, Phase 2b/3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with nAMD (ATMOSPHERE)
Read MoreStatus: Active: Enrollment Closed
OAKS/GALE
A Phase III, Multi-Center, Randomized, Double-Masked, Sham Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) (OAKS)
Read MoreStatus: Active: Enrollment Closed
DERBY/GALE
A Phase III, Multi-Center, Randomized, Double-Masked, Sham Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) (DERBY)
Read MoreStatus: Active: Enrollment Closed
PULSAR
Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients with Neovascular Age-Related Macular Degeneration (PULSAR)
Read MoreStatus: Active: Enrollment Closed
BIM2
To identify whether genetic variation or polymorphism in genes that impact angiogenesis can be identified as biomarkers for responsiveness to anti-VEGF therapy in patients with neovascular age-related macular degeneration.
Read MoreChoroidal Melanoma
Status: Active: Recruiting
AURA
A Phase 2 Trial of AU-011 Via Suprachoroidal Administration with a Dose Escalation Phase (Open-label, Ascending Single and Repeat Dose) and a Randomized, Masked Dose Expansion Phase Designed to Evaluate the Safety and Efficacy of AU-011 in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma
Read MoreCornea
Status: Active: Recruiting
Zoster Eye Disease Study (ZEDS)
A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Suppressive Valacyclovir for One Year in Immunocompetent Study Participants with an Episode of Dendriform Epithelial Keratitis, Stromal Keratitis, Endothelial Keratitis, and/or Iritis Due to Herpes Zoster Ophthalmicus (HZO) in the Year Prior to Enrollment (ZEDS)
Read MoreStatus: Active: Recruiting
oGVHD
Scleral Contact Lens Reduction of Dry Eye Inflammation in Patients with Graft-Versus-Host Disease (GVHD)
Read MoreDiabetic Macular Edema
Status: Active: Recruiting
UNITY
A Phase 2a, Prospective, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Safety, Tolerability and Evidence of Activity of a Single Intravitreal Injection of UBX1325 in Patients with Diabetic Macular Edema
Read MoreStatus: Active: Enrollment Closed
YOSEMITE/RHONE-X
A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients with Diabetic Macular Edema (YOSEMITE)
Read MoreStatus: Active: Enrollment Closed
KESTREL
A Two-year, Three-arm, Randomized, Double-masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Adult Patients with Visual Impairment Due to Diabetic Macular Edema (KESTREL)
Read MoreGenetics
Status: Active: Recruiting
GENETIC EYE DISORDERS
To identify the gene or genes responsible for developmental causes of blindness in the world, and to establish a Pediatric Ophthalmic Genetics and Research Program at the University of Wisconsin – Madison.
Read MoreStatus: Active: Recruiting
MYOPIA
To identify genes that are involved in eye growth specifically in individuals and families with nearsightedness (myopia).
Read MoreInherited Retinal Diseases
Status: Active: Recruiting
SOLSTICE
A Long-term Follow-up Study to Evaluate the Safety and Efficacy of Retinal Gene Therapy in Subjects with Choroideremia Treated Previously with Adeno-Associated Viral Vector Encoding Rab Escort Protein-1 (AAV2-REP1) in an Antecedent Study (SOLSTICE)
Read MoreStatus: Active: Recruiting
AGTC B3
A Multiple-Site, Phase 1/2, Safety and Efficacy Trial of a Recombinant Adeno-associated Virus Vector Expressing CNGB3 (rAAV2tYF-PR1.7-hCNGB3) in Patients with Congenital Achromatopsia Caused by Mutations in the CNGB3 Gene
Read MoreStatus: Active: Recruiting
AGTC A3
A Multiple-Site, Phase 1/2, Safety and Efficacy Trial of AGTC 402, a Recombinant Adeno-associated Virus Vector Expressing CNGA3, in Patients with Congenital Achromatopsia Caused by Mutations in the CNGA3 Gene
Read MoreStatus: Active: Recruiting
Pro-EYS
Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS).
Read MoreStatus: Active: Recruiting
XOLARIS
To gain a better understanding of disease progression over time in male subjects with X-linked retinitis pigmentosa (XLRP).
Read MoreStatus: Active: Enrollment Closed
CHM SURVEY TRIAL
To assess health-related quality of life, health utility, work productivity, and impact on daily activities in patients/caregivers with CHM at different stages of disease progression.
Read MoreOther Explorations
Status: Active: Enrollment Closed
PRIM
To determine risk factors, prevalence, and incidence of maculopathy in UW patients with interstitial cystitis on pentosan polysulfate (PPS).
Read MorePediatrics
Status: Active: Recruiting
AS OCT2
To investigate whether anatomical differences in Schlemm’s canal and anterior segment structures are associated with the development of glaucoma in pediatric patients that undergo cataract surgery.
Read MoreStatus: Active: Recruiting
CLN-0500
A Randomized, Parallel-Arm, Active Control, Multicenter Study Assessing the Safety and Efficacy of Dextenza for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract
Read MoreStatus: Active: Enrollment Closed
INTERMITTENT EXOTROPIA STUDY (IXT1)
A Randomized Trial of Bilateral Lateral Rectus Recession versus Unilateral Lateral Rectus Recession with Medial Rectus Resection for Intermittent Exotropia
Read MoreStatus: Active: Enrollment Closed
CHAMP
A 3-Arm Randomized, Double-Masked, Placebo-Controlled, Phase 3 Study of NVK-002 in Children with Myopia (CHAMP)
Read MoreRetinal Vein Occlusion
Status: Active: Enrollment Closed
RAPTOR
An Eighteen-Month, Two-Arm, Randomized, Double Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Adult Patients with Visual Impairment Due to Macular Edema Secondary to Branch Retinal Vein Occlusion (RAPTOR)
Read MoreStatus: Active: Enrollment Closed
RAVEN
An Eighteen-Month, Two-Arm, Randomized, Double Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Adult Patients with Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
Read MoreUveitis
Status: Active: Recruiting
LUMINA
A Phase III, Multicenter, Sham-Controlled, Randomized, Double-Masked Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye (LUMINA)
Read MoreStatus: Active: Recruiting
MICROBIOME
To compare the gut microbiota composition in pediatric Juvenile Idiopathic Arthritis (JIA) uveitis patients to JIA patients without uveitis and to healthy controls.
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