Clinical Trials

Age-Related Macular Degeneration

Status: Active: Recruiting

ATMOSPHERE

A Randomized, Partially Masked, Controlled, Phase 2b/3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with nAMD (ATMOSPHERE)

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Status: Active: Recruiting

HONU

The purpose of this study is to assess iAMD disease progression, by the timeline and rates of conversion for high-risk iAMD at baseline to more advanced AMD stages.

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Status: Active: Recruiting

VILLA

To evaluate safety and tolerability of the Port Delivery System (PDS) in patients with neovascular age-related macular degeneration (nAMD).

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Status: Active: Recruiting

CONCERTO

To determine the safety and effectiveness of the smaller incision, new generation (SING), implantable miniature telescope (IMT) in patients with moderate-severe central vision loss due to late-stage age-related macular degeneration (AMD).

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Status: Active: Enrollment Closed

PULSAR

Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients with Neovascular Age-Related Macular Degeneration (PULSAR)

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Status: Active: Enrollment Closed

GALE

To assess the long-term efficacy and safety of multiple intravitreal injections of APL-2 in subjects with geographic atrophy secondary to age-related macular degeneration.

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Choroidal Melanoma

Status: Active: Recruiting

AURA

A Phase 2 Trial of AU-011 Via Suprachoroidal Administration with a Dose Escalation Phase (Open-label, Ascending Single and Repeat Dose) and a Randomized, Masked Dose Expansion Phase Designed to Evaluate the Safety and Efficacy of AU-011 in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma

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Cornea

Status: Active: Recruiting

Zoster Eye Disease Study (ZEDS)

A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Suppressive Valacyclovir for One Year in Immunocompetent Study Participants with an Episode of Dendriform Epithelial Keratitis, Stromal Keratitis, Endothelial Keratitis, and/or Iritis Due to Herpes Zoster Ophthalmicus (HZO) in the Year Prior to Enrollment (ZEDS)

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Status: Active: Recruiting

oGVHD

Scleral Contact Lens Reduction of Dry Eye Inflammation in Patients with Graft-Versus-Host Disease (GVHD)

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Diabetic Macular Edema

Status: Active: Enrollment Closed

YOSEMITE/RHONE-X

A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients with Diabetic Macular Edema (YOSEMITE)

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Genetics

Status: Active: Recruiting

GENETIC EYE DISORDERS

To identify the gene or genes responsible for developmental causes of blindness in the world, and to establish a Pediatric Ophthalmic Genetics and Research Program at the University of Wisconsin – Madison.

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Status: Active: Recruiting

MYOPIA

To identify genes that are involved in eye growth specifically in individuals and families with nearsightedness (myopia).

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Glaucoma

Status: Active: Recruiting

COAST

Clarifying the Optimal Application of SLT Therapy Trial (COAST)

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Inherited Retinal Diseases

Status: Active: Enrollment Closed

SOLSTICE

A Long-term Follow-up Study to Evaluate the Safety and Efficacy of Retinal Gene Therapy in Subjects with Choroideremia Treated Previously with Adeno-Associated Viral Vector Encoding Rab Escort Protein-1 (AAV2-REP1) in an Antecedent Study (SOLSTICE)

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Status: Active: Enrollment Closed

Pro-EYS

Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS).

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Status: Active: Enrollment Closed

XOLARIS

To gain a better understanding of disease progression over time in male subjects with X-linked retinitis pigmentosa (XLRP).

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Oculoplastics

Status: Active: Recruiting

TED

A Phase 2b, Randomized, Double-Mask, Placebo-Controlled, Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Linsitinib in Subjects with Active, Moderate to Severe Thyroid Eye Disease (TED)

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Pediatrics

Status: Active: Recruiting

AS OCT2

To investigate whether anatomical differences in Schlemm’s canal and anterior segment structures are associated with the development of glaucoma in pediatric patients that undergo cataract surgery.

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Status: Active: Enrollment Closed

INTERMITTENT EXOTROPIA STUDY (IXT1)

A Randomized Trial of Bilateral Lateral Rectus Recession versus Unilateral Lateral Rectus Recession with Medial Rectus Resection for Intermittent Exotropia

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Status: Active: Enrollment Closed

CHAMP

A 3-Arm Randomized, Double-Masked, Placebo-Controlled, Phase 3 Study of NVK-002 in Children with Myopia (CHAMP)

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Uveitis

Status: Active: Recruiting

MICROBIOME

To compare the gut microbiota composition in pediatric Juvenile Idiopathic Arthritis (JIA) uveitis patients to JIA patients without uveitis and to healthy controls.

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Status: Active: Recruiting

IZOKIBEP (IL-17A)

To assess the safety, tolerability, and immunogenicity of izokibep in subjects with active non-infectious, intermediate-, posterior- or pan-uveitis requiring high-dose steroids.

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