Retinal cells grown from stem cells can reach out and connect with neighbors, according to a new study, completing a “handshake” that may show the cells are ready for trials in humans with degenerative eye disorders.
Gamm Lab
Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment phenotype that models advanced retinitis pigmentosa.
PubMed ID: 36206764 Author(s): Mayerl SJ, Bajgai S, Ludwig AL, Jager LD, Williams BN, Bacig C, Stoddard C, Sinha D, Philpot BD, Gamm DM. Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment …
Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs.
PubMed ID: 35905738 Author(s): Ripolles-Garcia A, Dolgova N, Phillips MJ, Savina S, Ludwig AL, Stuedemann SA, Nlebedum U, Wolfe JH, Garden OA, Maminishkis A, Amaral J, Bharti K, Gamm DM, Aguirre GD, Beltran WA. Systemic …
In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids.
PubMed ID: 35781966 Author(s): Samimi K, Pattnaik BR, Capowski EE, Saha K, Gamm DM, Skala MC. In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids. Biomed Opt …
Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution.
PubMed ID: 35584680 Author(s): Rempel SK, Welch MJ, Ludwig AL, Phillips MJ, Kancherla Y, Zack DJ, Gamm DM, Gómez TM. Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution. …
Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.
PubMed ID: 35245468 Author(s): Saha A, Capowski E, Fernandez Zepeda MA, Nelson EC, Gamm DM, Sinha R. Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea. …
Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.
PubMed ID: 35104442 Author(s): Saha A, Capowski E, Fernandez Zepeda MA, Nelson EC, Gamm DM, Sinha R. Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea. …
Outer Retinal Cell Replacement: Putting the Pieces Together.
PubMed ID: 34724034 Author(s): Ludwig AL, Gamm DM. Outer Retinal Cell Replacement: Putting the Pieces Together. Transl Vis Sci Technol. 2021 Aug 12;10(10):15. doi: 10.1167/tvst.10.10.15. PMID 34724034 Journal: Translational Vision Science & Technology, Volume 10, …
The NIH Somatic Cell Genome Editing program.
PubMed ID: 33828315 Author(s): Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac …