PubMed ID: 37575875 Author(s): Lee IK, Xie R, Luz-Madrigal A, Min S, Zhu J, Jin J, Edwards KL, Phillips MJ, Ludwig AL, Gamm DM, Gong S, Ma Z. Micromolded honeycomb scaffold design to support the …
Gamm Lab
Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy.
PubMed ID: 37561581 Author(s): Kabra M, Shahi PK, Wang Y, Sinha D, Spillane A, Newby GA, Saxena S, Tong Y, Chang Y, Abdeen AA, Edwards KL, Theisen CO, Liu DR, Gamm DM, Gong S, Saha …
UW Researchers Will Develop Gene Editing Therapy to Treat Blindness
A new study by UW researchers will test gene editing therapy to treat blindness. The collaborative project involves a team of ophthalmology researchers and biomedical engineers.
A versatile laser-induced porcine model of outer retinal and choroidal degeneration for preclinical testing.
PubMed ID: 37288665 Author(s): Barone F, Amaral J, Bunea I, Farnoodian M, Gupta R, Gupta R, Baker D, Phillips MJ, Blanch RJ, Maminishkis A, Gamm DM, Bharti K. A versatile laser-induced porcine model of outer …
Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures.
PubMed ID: 36598946 Author(s): Ludwig AL, Mayerl SJ, Gao Y, Banghart M, Bacig C, Fernandez Zepeda MA, Zhao X, Gamm DM. Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures. Proc Natl …
Lab-Grown Retinal Eye Cells Open Door For Clinical Trials to Treat Blindness
Retinal cells grown from stem cells can reach out and connect with neighbors, according to a new study, completing a “handshake” that may show the cells are ready for trials in humans with degenerative eye disorders.
Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment phenotype that models advanced retinitis pigmentosa.
PubMed ID: 36206764 Author(s): Mayerl SJ, Bajgai S, Ludwig AL, Jager LD, Williams BN, Bacig C, Stoddard C, Sinha D, Philpot BD, Gamm DM. Human retinal organoids harboring IMPG2 mutations exhibit a photoreceptor outer segment …
Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs.
PubMed ID: 35905738 Author(s): Ripolles-Garcia A, Dolgova N, Phillips MJ, Savina S, Ludwig AL, Stuedemann SA, Nlebedum U, Wolfe JH, Garden OA, Maminishkis A, Amaral J, Bharti K, Gamm DM, Aguirre GD, Beltran WA. Systemic …
In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids.
PubMed ID: 35781966 Author(s): Samimi K, Pattnaik BR, Capowski EE, Saha K, Gamm DM, Skala MC. In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids. Biomed Opt …